SARS-CoV-2 envelope protein topology in eukaryotic membranes

SARS-CoV-2 envelope protein topology in eukaryotic membranes

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SARS-CoV-2 envelope protein topology in eukaryotic membranes

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Duart, Gerard; García Murria, María Jesús; Grau, Brayan; Acosta-Cáceres, José M.; Martínez Gil, Luis; Mingarro Muñoz, Ismael
This document is a artículoDate2020

Coronavirus E protein is a small membrane protein found in the virus envelope. Different coronavirus E proteins share striking biochemical and functional similarities, but sequence conservation is limited. In this report, we studied the E protein topology from the new SARS-CoV-2 virus both in microsomal membranes and in mammalian cells. Experimental data reveal that E protein is a single-spanning membrane protein with the N-terminus being translocated across the membrane, while the C-terminus is exposed to the cytoplasmic side (Ntlum/Ctcyt). The defined membrane protein topology of SARS-CoV-2 E protein may provide a useful framework to understand its interaction with other viral and host components and contribute to establish the basis to tackle the pathogenesis of SARS-CoV-2.
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