Left ventricular Myocardial dysfunction in arrhythmogenic cardiomyopathy with left ventricular involvement: A door to improving diagnosis.
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Left ventricular Myocardial dysfunction in arrhythmogenic cardiomyopathy with left ventricular involvement: A door to improving diagnosis.

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Left ventricular Myocardial dysfunction in arrhythmogenic cardiomyopathy with left ventricular involvement: A door to improving diagnosis.

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dc.contributor.author Vives-Gilabert, Yolanda
dc.contributor.author Sanz-Sánchez, Jorge
dc.contributor.author Molina Aguilar, Pilar
dc.contributor.author Cebrián, Antonio
dc.contributor.author Igual, Begoña
dc.contributor.author Calvillo-Batllés, Pilar
dc.contributor.author Domingo, Diana
dc.contributor.author Millet, José
dc.contributor.author Martínez-Dolz, Luis
dc.contributor.author Castells, Francisco
dc.contributor.author Zorio Grima, Esther
dc.date.accessioned 2021-04-19T07:28:22Z
dc.date.available 2021-04-19T07:28:22Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/10550/78748
dc.description.abstract Background: Diagnostic Task Force Criteria (TFC) for arrhythmogenic cardiomyopathy (AC) exhibit poor performance for left dominant forms. TFC only include right ventricular (RV) dysfunction (akinesia, dyssynchrony, volumes and ejection fraction). Moreover, cardiac magnetic resonance imaging (CMRI) assessment of left ventricular (LV) dyssynchrony has hitherto not been described. Thus, we aimed to comprehensively characterize LV CMRI behavior in AC patients. Methods: Thirty-five AC patients with LV involvement and twenty-three non-affected family members (controls) were enrolled. Feature-tracking analysis was applied to cine CMRI to assess LV ejection fraction (LVEF), LV endsystolic and end-diastolic volume indexes, strain values and dyssynchrony. Regions with more frequent strain and dyssynchrony impairment were also studied. Results: Radial dyssynchrony and LVEF were selected (sensitivities 54.3% and 48.6%, respectively at 100% specificity), with a threshold of 70 ms for radial dyssynchrony and 48.5% for LVEF. 71.4% of patients exceeded these thresholds (31.4% both, 22.9% only dyssynchrony and 17.1% only LVEF). Considering these cut-off values as a novel combined criterion, 30% of patients with 'borderline' or 'possible' AC following 2010 TFC would move to a 'definite' AC diagnosis. Strain was globally impaired whereas dyssynchronous regions were more often apical and located at the inferolateral wall. Conclusions: Mirroring the RV evaluation, we suggest including LVEF and LV dyssynchrony to improve the diagnosis of AC. Two independent mechanisms can be claimed in AC patients with LV involvement: 1) decreased myocardial deformation with global LV affectation and 2) delayed myocardial contraction at localized regions.
dc.language.iso eng
dc.relation.ispartof International Journal of Cardiology, 2019
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Vives-Gilabert, Yolanda Sanz-Sánchez, Jorge Molina Aguilar, Pilar Cebrián, Antonio Igual, Begoña Calvillo-Batllés, Pilar Domingo, Diana Millet, José Martínez-Dolz, Luis Castells, Francisco Zorio Grima, Esther 2019 Left ventricular Myocardial dysfunction in arrhythmogenic cardiomyopathy with left ventricular involvement: A door to improving diagnosis. International Journal of Cardiology
dc.subject Patologia
dc.subject Cor
dc.title Left ventricular Myocardial dysfunction in arrhythmogenic cardiomyopathy with left ventricular involvement: A door to improving diagnosis.
dc.type info:eu-repo/semantics/article
dc.date.updated 2021-04-19T07:28:22Z
dc.identifier.idgrec 145251

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