Interplay Between MicroRNAs and Oxidative Stress in Ovarian Conditions with a Focus on Ovarian Cancer and Endometriosis.
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Interplay Between MicroRNAs and Oxidative Stress in Ovarian Conditions with a Focus on Ovarian Cancer and Endometriosis.

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Interplay Between MicroRNAs and Oxidative Stress in Ovarian Conditions with a Focus on Ovarian Cancer and Endometriosis.

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dc.contributor.author Marí Alexandre, Josep
dc.contributor.author Carcelén Pellín, Antonio
dc.contributor.author Agababyan, Cristina
dc.contributor.author Moreno Manuel, Andrea
dc.contributor.author García Oms, Javier
dc.contributor.author Calabuig Fariñas, Silvia
dc.contributor.author Gilabert Estellés, Juan
dc.date.accessioned 2021-03-09T12:25:06Z
dc.date.available 2021-03-09T12:25:06Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/10550/78213
dc.description.abstract Ovarian cancer and endometriosis are two distinct gynaecological conditions that share many biological aspects incuding proliferation, invasion of surrounding tissue, inflammation, inhibition of apoptosis, deregulation of angiogenesis and the ability to spread at a distance. miRNAs are small non-coding RNAs (19-22 nt) that act as post-transcriptional modulators of gene expression and are involved in several of the aforementioned processes. In addition, a growing body of evidence supports the contribution of oxidative stress (OS) to these gynaecological diseases: increased peritoneal OS due to the decomposition of retrograde menstruation blood facilitates both endometriotic lesion development and fallopian tube malignant transformation leading to high-grade serous ovarian cancer (HGSOC). Furthermore, as HGSOC develops, increased OS levels are associated with chemoresistance. Finally, continued bleeding within ovarian endometrioma raises OS levels and contributes to the development of endometriosis-associated ovarian cancer (EAOC). Therefore, this review aims to address the need for a better understanding of the dialogue between miRNAs and oxidative stress in the pathophysiology of ovarian conditions: endometriosis, EAOC and HGSOC
dc.language.iso eng
dc.relation.ispartof International Journal Of Molecular Sciences, 2019, vol. 20, num. 21, p. pii: E5322
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Marí Alexandre, Josep Carcelén Pellín, Antonio Agababyan, Cristina Moreno Manuel, Andrea García Oms, Javier Calabuig Fariñas, Silvia Gilabert Estellés, Juan 2019 Interplay Between MicroRNAs and Oxidative Stress in Ovarian Conditions with a Focus on Ovarian Cancer and Endometriosis. International Journal Of Molecular Sciences 20 21 pii: E5322
dc.subject Ginecologia
dc.subject Càncer
dc.title Interplay Between MicroRNAs and Oxidative Stress in Ovarian Conditions with a Focus on Ovarian Cancer and Endometriosis.
dc.type info:eu-repo/semantics/article
dc.date.updated 2021-03-09T12:25:06Z
dc.identifier.doi https://doi.org/10.3390/ijms20215322
dc.identifier.idgrec 136076

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