Red propolis hydroalcoholic extract inhibits the formation of Candida albicans biofilms on denture surface
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Red propolis hydroalcoholic extract inhibits the formation of Candida albicans biofilms on denture surface

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Red propolis hydroalcoholic extract inhibits the formation of Candida albicans biofilms on denture surface

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dc.contributor.author Leite, Karla-Lorene-de França es
dc.contributor.author Martins, Mariana-Leonel es
dc.contributor.author de Medeiros, Mariana-Marinho-Davino es
dc.contributor.author Bezerra, Natanael-Victor-Furtunato es
dc.contributor.author Brito, Camila-Santos-de Mattos es
dc.contributor.author de Almeida, Leopoldina de Fátima Dantas es
dc.contributor.author Cavalcanti, Yuri-Wanderley es
dc.date.accessioned 2021-01-25T11:09:12Z
dc.date.available 2021-01-25T11:09:12Z
dc.date.issued 2020 es
dc.identifier.uri https://hdl.handle.net/10550/77499
dc.description.abstract To evaluate the antifungal activity of the red propolis hydroalcoholic extract (RPHE) against Candida albicans biofilms. The minimum inhibitory and fungicidal concentrations (MIC and MFC) of the RPHE were determined by the microdilution technique. C. albicans biofilms were formed on the surface of resin specimens preconditioned with artificial saliva (1h). The specimens (N=48) were equally divided according to the four solutions used for anti-biofilm evaluation (n=12 per group). After overnight incubation, biofilms were daily exposed (2x/day for 15 min) along 3 days with 3% RPHE, 0.12% chlorhexidine (CHX), 50,000 IU/mL nystatin (NYS) or saline (0.9% NaCl). Biofilms were analyzed regarding the number of viable microorganisms (CFU/mL), the metabolic activity (MTT assay) and the proportion of hyphae (optical microscopy). The MIC and MFC of RPHE were respectively 0.29 mg/mL (0.03%) and 1.17 mg/mL (0.12%). There was no difference in the microorganisms? viability (CFU/mL) among groups treated with RPHE (4.92×103), CHX (3.33×102) or NYS (6.8×104), being all of them different from NaCl (3.93×107) (p<0.05). The CHX (0.133) had the lowest metabolic activity (p<0.05), followed by RPHE (0.292) and NYS (0.302) (p>0.05). All experimental groups had a mean proportion of hyphae <10%, lower than NaCl (70%). RPHE has antifungal activity against C. albicans biofilms, suggesting its use for the biofilm control on denture surfaces. es
dc.source Leite, Karla-Lorene-de França ; Martins, Mariana-Leonel ; de Medeiros, Mariana-Marinho-Davino ; Bezerra, Natanael-Victor-Furtunato ; Brito, Camila-Santos-de Mattos ; de Almeida, Leopoldina de Fátima Dantas ; Cavalcanti, Yuri-Wanderley. Red propolis hydroalcoholic extract inhibits the formation of Candida albicans biofilms on denture surface. En: Journal of Clinical and Experimental Dentistry, 12 7 2020: 626-631 es
dc.title Red propolis hydroalcoholic extract inhibits the formation of Candida albicans biofilms on denture surface es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/jced.56843 es

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