Short time guided bone regeneration using beta-tricalcium phosphate with and without fibronectin. An experimental study in rats
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Short time guided bone regeneration using beta-tricalcium phosphate with and without fibronectin. An experimental study in rats

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Short time guided bone regeneration using beta-tricalcium phosphate with and without fibronectin. An experimental study in rats

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dc.contributor.author Sánchez-Garcés, María Angeles es
dc.contributor.author Camps Font, Octavi es
dc.contributor.author Escoda Francolí, Jaume es
dc.contributor.author Muñoz Guzon, Fernando M. es
dc.contributor.author Toledano-Serrabona, Jorge es
dc.contributor.author Gay-Escoda, Cosme es
dc.date.accessioned 2021-01-15T09:31:08Z
dc.date.available 2021-01-15T09:31:08Z
dc.date.issued 2020 es
dc.identifier.uri https://hdl.handle.net/10550/77162
dc.description.abstract  The aim of this histomorphometric study was to assess the bone regeneration potential of beta-tricalcium phosphate with fibronectin (β-TCP-Fn) in critical-sized defects (CSDs) in rats calvarial, to know whether Fn improves the new bone formation in a short time scope.  CSDs were created in 30 Sprague Dawley rats, and divided into four groups (2 or 6 weeks of healing) and type of filling β-TCP-Fn, β-TCP, empty control). Variables studied were augmented area (AA), gained tissue (GT), mineralized/non mineralized bone matrix (MBM/NMT) and bone substitute (BS). 60 samples at 2 and six weeks were evaluated. AA was higher for treatment groups comparing to controls (p < 0.001) and significant decrease in BS area in the β-TCP-Fn group from 2 to 6 weeks (p = 0.031). GT was higher in the β-TCP-Fn group than in the controls expressed in % (p = 0.028) and in mm2 (p = 0.011), specially at two weeks (p=0.056).  Both β-TCP biomaterials are effective as compared with bone defects left empty in maintaining the volume. GT in defects regeneration filed with β-TCP-Fn are significantly better in short healing time when comparing with controls but not for β-TCP used alone in rats calvarial CSDs. es
dc.source Sánchez-Garcés, María Angeles ; Camps Font, Octavi ; Escoda Francolí, Jaume ; Muñoz Guzon, Fernando M. ; Toledano-Serrabona, Jorge ; Gay-Escoda, Cosme. Short time guided bone regeneration using beta-tricalcium phosphate with and without fibronectin - An experimental study in rats. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 25 4 2020: 18- es
dc.title Short time guided bone regeneration using beta-tricalcium phosphate with and without fibronectin. An experimental study in rats es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.23564 es

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