High frequency of BRAF V600E mutation in Iranian population ameloblastomas
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High frequency of BRAF V600E mutation in Iranian population ameloblastomas

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High frequency of BRAF V600E mutation in Iranian population ameloblastomas

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dc.contributor.author Derakhshan, Samira es
dc.contributor.author Aminishakib, Pouyan es
dc.contributor.author Karimi, Abbas es
dc.contributor.author Saffar, Hiva es
dc.contributor.author Abdollahi, Alireza es
dc.contributor.author Mohammadpour, Hadis es
dc.contributor.author KharaziFard, Mohammad Javd es
dc.contributor.author Memarha, Amirreza es
dc.date.accessioned 2021-01-15T09:31:03Z
dc.date.available 2021-01-15T09:31:03Z
dc.date.issued 2020 es
dc.identifier.uri https://hdl.handle.net/10550/77151
dc.description.abstract Ameloblastoma is a common locally invasive but slow-growing neoplasm of the jaws with an odontogenic origin. Association between BRAF V600E mutation and clinicopathologic features and behavior of ameloblastoma remains controversial. This study aimed to evaluate BRAF V600E gene mutation and expression of its related proteins with clinicopathologic parameters in conventional ameloblastoma. 50 Formalin-fixed paraffin-embedded blocks were included in this study. Immunohistochemistry was done using rabbit monoclonal BRAF V600E mutation-specific antibody VE1. Quantitative real-time polymerase chain reaction assay was used for evaluating of BRAF V600E mutation. Expression of BRAF V600E antibody was Positive in 42 out of 50 cases (84%). 46 (92%) out of 50 specimens showed BRAF V600E mutation. There were 13 cases of recurrence (26%). 3 out of 4 cases with negative mutations did not show recurrence. We report the highest frequency (92%) of BRAF V600E mutation in ameloblastomas in the Iranian population. Although there was not a significant association between BRAF V600E?positive immunoexpression and recurrence and clinicopathologic parameters, its high frequency could emphasize its role as a therapeutic marker in the future. es
dc.source Derakhshan, Samira ; Aminishakib, Pouyan ; Karimi, Abbas ; Saffar, Hiva ; Abdollahi, Alireza ; Mohammadpour, Hadis ; KharaziFard, Mohammad Javd ; Memarha, Amirreza. High frequency of BRAF V600E mutation in Iranian population ameloblastomas. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 25 4 2020: 7- es
dc.title High frequency of BRAF V600E mutation in Iranian population ameloblastomas es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.23519 es

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