Clinical-pathological and sociodemographic factors associated with the distant metastasis and overall survival of oral cavity and oropharynx squamous cell carcinoma
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Clinical-pathological and sociodemographic factors associated with the distant metastasis and overall survival of oral cavity and oropharynx squamous cell carcinoma

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Clinical-pathological and sociodemographic factors associated with the distant metastasis and overall survival of oral cavity and oropharynx squamous cell carcinoma

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dc.contributor.author Silva, Paulo-Goberlânio-de Barros es
dc.contributor.author Fontes-Borges, Marcela Maria es
dc.contributor.author Costa-Dias, Camila es
dc.contributor.author Mota-Lemos, José Vitor es
dc.contributor.author Socorro-Saldanha-Cunha, Maria do Perpétuo es
dc.contributor.author Fernandes-Souza, Eric es
dc.contributor.author Sousa-Dantas, Thinali es
dc.contributor.author Sousa, Fabrício Bitu es
dc.date.accessioned 2021-01-15T09:07:35Z
dc.date.available 2021-01-15T09:07:35Z
dc.date.issued 2020 es
dc.identifier.uri https://hdl.handle.net/10550/77124
dc.description.abstract The objective of this study was to evaluate the influence of clinical-pathological and sociodemographic factors on the prevalence of distant metastasis (DM) and overall survival in patients with oral cavity and oropharynx squamous cell carcinoma (OOSCC). Cross-sectional study based on the records of 404 OOSCC patients evaluated for DM, covering the period 2000-2014. We analysed the influence of age, sex, level of schooling, primary tumor subsite, treatment, marital status, family history of cancer, history of smoking and alcohol consumption, type of health care coverage (private vs. public) and overall survival. Findings were submitted to Fisher?s exact test, Pearson?s chi-squared test, Mantel-Cox log-rank testing and multinomial and Cox regression analysis (SPSS v. 20.0; p<0.05). The prevalence of DM was 5.4% (22/404). The respiratory tract was the most affected DM site (n=9; 40.9%). Male sex (p=0.049), oropharyngeal primary tumor (p=0.008), stage T3-4 (p=0.022), lymph node metastasis (N+) (p<0.001) and palliative treatment (p=0.005) were directly associated with DM. Patients with oral primary tumours (p=0.343) and primary oropharyngeal tumours (p=0.242) did not differ significantly with regard to the prevalence of DM. N+ was an independent risk factor for DM (p=0.017). Five variables independently reduced overall survival: male sex (p=0.035), age >65 years (p=0.046), indigenous/brown racial type (p=0.045), palliative treatment (p=0.035) and DM (p=0.048). Lymph node metastasis independently increased the prevalence of DM and, along with male sex, older age, brown racial type and palliative treatment, was independently associated with poor prognosis in patients with OOSCC. es
dc.source Silva, Paulo-Goberlânio-de Barros ; Fontes-Borges, Marcela Maria ; Costa-Dias, Camila ; Mota-Lemos, José Vitor ; Socorro-Saldanha-Cunha, Maria do Perpétuo ; Fernandes-Souza, Eric ; Sousa-Dantas, Thinali ; Sousa, Fabrício Bitu. Clinical-pathological and sociodemographic factors associated with the distant metastasis and overall survival of oral cavity and oropharynx squamous cell carcinoma. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 25 3 2020: 1- es
dc.title Clinical-pathological and sociodemographic factors associated with the distant metastasis and overall survival of oral cavity and oropharynx squamous cell carcinoma es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.23410 es

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