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Oral leukoplakia, a clinical-histopathological study in 412 patients

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Oral leukoplakia, a clinical-histopathological study in 412 patients

dc.contributor.author	Rubert, A.	es
dc.contributor.author	Bagán Debón, Leticia	es
dc.contributor.author	Bagán Sebastián, José Vicente	es
dc.date.accessioned	2020-10-23T10:30:11Z
dc.date.available	2020-10-23T10:30:11Z
dc.date.issued	2020	es
dc.identifier.uri	https://hdl.handle.net/10550/76062
dc.description.abstract	A retrospective clinical-histopathological study was made of the evolution of oral leukoplakia over time, staging the disease according to the classification of van der Waal. A study was made of 412 patients with oral leukoplakia, analyzing the corresponding clinical factors and histopathological findings; assessing associations between the different clinical presentations and epithelial dysplasia; and evaluating the factors influencing malignant transformation of the lesions. Clinically, homogeneous presentations were seen to predominate (n = 336, 81.6%), while histologically most of the lesions exhibited no dysplastic changes (n = 271; 65.7%). Stage 1 of the van der Waal classification was the most common presentation (n = 214; 51.9%). The lesion malignization rate was 8.3%, and the factors associated to a significantly increased malignization risk were non-homogeneous OL lesions (p=0.00), lesion location in the tongue (p=0.00), and the presence of epithelial dysplasia (p=0.00). In our series of patients with oral leukoplakia, malignization was associated to the less common clinical presentations of the disease, i.e., non-homogeneous lesions, and the latter tended to exhibit high grade epithelial dysplasia.	es
dc.source	Rubert, A. ; Bagán Debón, Leticia ; Bagán Sebastián, José Vicente. Oral leukoplakia, a clinical-histopathological study in 412 patients. En: Journal of Clinical and Experimental Dentistry, 12 6 2020: 540-546	es
dc.title	Oral leukoplakia, a clinical-histopathological study in 412 patients	es
dc.type	info:eu-repo/semantics/article	en
dc.type	info:eu-repo/semantics/publishedVersion	en
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/jced.57091	es