Comparison of salivary cytokines levels among individuals with Down syndrome, cerebral palsy and normoactive
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Comparison of salivary cytokines levels among individuals with Down syndrome, cerebral palsy and normoactive

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Comparison of salivary cytokines levels among individuals with Down syndrome, cerebral palsy and normoactive

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dc.contributor.author Habibe, Carolina-Hartung es
dc.contributor.author Yoshida, Rosemeire-Arai es
dc.contributor.author Gorjão, Renata es
dc.contributor.author Gutierrez, Gabriela-Mancia es
dc.contributor.author Heller, Debora es
dc.contributor.author Birbrair, Alexander es
dc.contributor.author Santos, Maria-Teresa-Botti-Rodrigues es
dc.date.accessioned 2020-10-22T11:51:09Z
dc.date.available 2020-10-22T11:51:09Z
dc.date.issued 2020 es
dc.identifier.uri https://hdl.handle.net/10550/76041
dc.description.abstract Individuals with Down syndrome (DS) present increased susceptibility to infections and high prevalence of periodontal disease. The objective of this study is to evaluate the salivary concentrations of IL-1?, IL-6, IL-8, IL-10, TNF? and IL-12p70 of DS individuals and compare to cerebral palsy (CP) and normoactive patients (all with gingivitis). Twenty-two individuals with DS, 24 with CP and 22 normoactive participated in this cross-sectional study. Salivary flow rate, osmolality rate, Oral Hygiene Index, Gingival Index (GI) and salivary inflammatory markers IL-1?, IL-6, IL-8, IL-10, TNF? and IL-12p70 were evaluated. Shapiro-Wilks, Chi-square, ANOVA One-Way and Kruskal Wallis tests were applied with significance level at 5%. The groups were homogenous for gender, age, and IL12p70 cytokine (p>0.05). GI was significantly higher in DS compared to CP and healthy (p<0.05). CP presented reduced salivary flow and increased osmolality rate. CP showed significantly higher values for TNF?, IL10, and IL6 compared to DS and normoactive (p<0.05). DS and CP presented significantly higher values of IL-1? and IL8 compared to normoactive (p<0.05). Individuals with CP have higher risk to develop periodontal disease due to reduced salivary flow rate, increased salivary osmolality rate and elevated TNF?, IL-10, IL-6 compared to DS. es
dc.source Habibe, Carolina-Hartung ; Yoshida, Rosemeire-Arai ; Gorjão, Renata ; Gutierrez, Gabriela-Mancia ; Heller, Debora ; Birbrair, Alexander ; Santos, Maria-Teresa-Botti-Rodrigues. Comparison of salivary cytokines levels among individuals with Down syndrome, cerebral palsy and normoactive. En: Journal of Clinical and Experimental Dentistry, 12 5 2020: 446-451 es
dc.title Comparison of salivary cytokines levels among individuals with Down syndrome, cerebral palsy and normoactive es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/jced.56336 es

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