Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy.
NAGIOS: RODERIC FUNCIONANDO

Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy.

DSpace Repository

Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy.

Show simple item record

dc.contributor.author Cuadrado Godia, Elisa
dc.contributor.author Regueiro, Ander
dc.contributor.author Núñez Villota, Julio
dc.contributor.author Díaz Ricard, Maribel
dc.contributor.author Novella del Campo, Susana
dc.contributor.author Oliveras, Anna
dc.contributor.author Valverde, Miguel A.
dc.contributor.author Marrugat, Jaume
dc.contributor.author Ois, Angel
dc.contributor.author Giralt-Steinhauer, Eva
dc.contributor.author Sanchís, Juan
dc.contributor.author Escolar, Ginés
dc.contributor.author Hermenegildo, Carlos
dc.contributor.author Heras, Magda
dc.contributor.author Roquer, Jaume
dc.date.accessioned 2020-10-01T08:24:50Z
dc.date.available 2020-10-01T08:24:50Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/10550/75717
dc.description.abstract Introduction: The aim of this study was to determine prognostic factors for the risk of new vascular events during the first 6 months after acute myocardial infarction (AMI) or atherothrombotic stroke (AS). We were interested in the prognostic role of endothelial progenitor cells (EPC) and circulating endothelial cells (CEC). Methods: Between February 2009 and July 2012, 100 AMI and 50 AS patients were consecutively studied in three Spanish centres. Patients with previously documented coronary artery disease or ischemic strokes were excluded. Samples were collected within 24h of onset of symptoms. EPC and CEC were studied using flow cytometry and categorized by quartiles. Patients were followed for up to 6 months. NVE was defined as new acute coronary syndrome, transient ischemic attack (TIA), stroke, or any hospitalization or death from cardiovascular causes. The variables included in the analysis included: vascular risk factors, carotid intima-media thickness (IMT), atherosclerotic burden and basal EPC and CEC count. Multivariate survival analysis was performed using Cox regression analysis. Results: During follow-up, 19 patients (12.66%) had a new vascular event (5 strokes; 3 TIAs; 4 AMI; 6 hospitalizations; 1 death). Vascular events were associated with age (P = 0.039), carotid IMT≥0.9 (P = 0.044), and EPC count (P = 0.041) in the univariate analysis. Multivariate Cox regression analysis showed an independent association with EPC in the lowest quartile (HR: 10.33, 95%CI (1.22-87.34), P = 0.032] and IMT≥0.9 [HR: 4.12, 95%CI (1.21-13.95), P = 0.023]. Conclusions: Basal EPC and IMT≥0.9 can predict future vascular events in patients with AMI and AS, but CEC count does not affect cardiovascular risk.
dc.language.iso eng
dc.relation.ispartof Plos One, 2015, vol. 10, num. 9, p. e0132415
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Cuadrado Godia, Elisa Regueiro, Ander Núñez Villota, Julio Díaz Ricard, Maribel Novella del Campo, Susana Oliveras, Anna Valverde, Miguel A. Marrugat, Jaume Ois, Angel Giralt-Steinhauer, Eva Sanchís, Juan Escolar, Ginés Hermenegildo, Carlos Heras, Magda Roquer, Jaume 2015 Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy. Plos One 10 9 e0132415
dc.subject Cor
dc.subject Sistema cardiovascular
dc.title Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy.
dc.type info:eu-repo/semantics/article
dc.date.updated 2020-10-01T08:24:51Z
dc.identifier.idgrec 106972

View       (320.1Kb)

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search

Browse

Statistics