Changes in sex ratio from fertilization to birth in assisted-reproductive-treatment cycles
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Changes in sex ratio from fertilization to birth in assisted-reproductive-treatment cycles

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Changes in sex ratio from fertilization to birth in assisted-reproductive-treatment cycles

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dc.contributor.author Tarín, Juan José
dc.contributor.author García Pérez, Miguel A.
dc.contributor.author Hermenegildo, Carlos
dc.contributor.author Cano, Antonio
dc.date.accessioned 2020-10-01T08:06:40Z
dc.date.available 2020-10-01T08:06:40Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/10550/75716
dc.description.abstract Background: In Western gender-neutral countries, the sex ratio at birth is estimated to be approximately 1.06. This ratio is lower than the estimated sex ratio at fertilization which ranges from 1.07 to 1.70 depending on the figures of sex ratio at birth and differential embryo/fetal mortality rates taken into account to perform these estimations. Likewise, little is known about the sex ratio at implantation in natural and assisted-reproduction-treatment (ART) cycles. In this bioessay, we aim to estimate the sex ratio at fertilization and implantation using data from embryos generated by standard in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) in preimplantation genetic diagnosis cycles. Thereafter, we compare sex ratios at implantation and birth in cleavage- and blastocyst-stage-transfer cycles to propose molecular mechanisms accounting for differences in post-implantation male and female mortality and thereby variations in sex ratios at birth in ART cycles. Methods: A literature review based on publications up to December 2013 identified by PubMed database searches. Results: Sex ratio at both fertilization and implantation is estimated to be between 1.29 and 1.50 in IVF cycles and 1.07 in ICSI cycles. Compared with the estimated sex ratio at implantation, sex ratio at birth is lower in IVF cycles (1.03 after cleavage-stage transfer and 1.25 after blastocyst-stage transfer) but similar and close to unity in ICSI cycles (0.95 after cleavage-stage transfer and 1.04 after blastocyst-stage transfer). Conclusions: In-vitro-culture-induced precocious X-chromosome inactivation together with ICSI-induced decrease in number of trophectoderm cells in female blastocysts may account for preferential female mortality at early post-implantation stages and thereby variations in sex ratios at birth in ART cycles.
dc.language.iso eng
dc.relation.ispartof Reproductive Biology And Endocrinology, 2014, vol. 12, num. 56
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Tarín, Juan José García Pérez, Miguel A. Hermenegildo, Carlos Cano, Antonio 2014 Changes in sex ratio from fertilization to birth in assisted-reproductive-treatment cycles Reproductive Biology And Endocrinology 12 56
dc.subject Reproducció
dc.title Changes in sex ratio from fertilization to birth in assisted-reproductive-treatment cycles
dc.type info:eu-repo/semantics/article
dc.date.updated 2020-10-01T08:06:41Z
dc.identifier.doi https://doi.org/10.1186/1477-7827-12-56
dc.identifier.idgrec 093016

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