Conjugate alkynylation of electrophilic double bonds. From regioselectivity to enantioselectivity
NAGIOS: RODERIC FUNCIONANDO

Conjugate alkynylation of electrophilic double bonds. From regioselectivity to enantioselectivity

DSpace Repository

Conjugate alkynylation of electrophilic double bonds. From regioselectivity to enantioselectivity

Show simple item record

dc.contributor.author Blay Llinares, Gonzalo
dc.contributor.author Pedro, José Ramón
dc.contributor.author Sanz Marco, Amparo
dc.date.accessioned 2020-09-30T15:58:53Z
dc.date.available 2020-09-30T15:58:53Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/10550/75706
dc.description.abstract This review surveys the historical efforts addressed toward the development of the conjugate alkynylation reaction. The regio- and enantioselective conjugate alkynylation of electron-deficient double bonds, most commonly unsaturated carbonyl compounds, has been an elusive reaction for a long time. Intensive research during the last decades has resulted in the identification of a number of effective reagents and catalysts to perform this reaction. Non-stereoselective conjugate alkynylation of unsaturated carbonyl compounds was first achieved by using preformed alkynyl organometallics and later with terminal alkynes under catalytic conditions. These methods paved the way for the development of enantioselective procedures. After initial methods requiring stoichiometric amounts of chiral material, the findings by Corey on Ni-catalyzed addition of alkynylalanes and, particularly, by Carreira on Cu-catalyzed addition of terminal alkynes boosted the research on the development other asymmetric procedures catalyzed by Cu, Zn, Rh, Co, Ru and Pd complexes. The alkynylation of electrophilic alkenes conjugated with groups other than carbonyl and the alkynylation of extended conjugated systems are also discussed in the last part of this review.
dc.language.iso eng
dc.relation.ispartof Synthesis-Stuttgart, 2018, vol. 50, p. 3281-3306
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Blay Llinares, Gonzalo Pedro, José Ramón Sanz Marco, Amparo 2018 Conjugate alkynylation of electrophilic double bonds. From regioselectivity to enantioselectivity Synthesis-Stuttgart 50 3281 3306
dc.subject Química orgànica
dc.subject Catàlisi
dc.title Conjugate alkynylation of electrophilic double bonds. From regioselectivity to enantioselectivity
dc.type info:eu-repo/semantics/article
dc.date.updated 2020-09-30T15:58:53Z
dc.identifier.doi https://doi.org/10.1055/s-0037-1610182
dc.identifier.idgrec 126705

View       (949.5Kb)

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search

Browse

Statistics