Enantioselective Synthesis of 5‑Trifluoromethyl-2-oxazolines under Dual Silver/Organocatalysis
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Enantioselective Synthesis of 5‑Trifluoromethyl-2-oxazolines under Dual Silver/Organocatalysis

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Enantioselective Synthesis of 5‑Trifluoromethyl-2-oxazolines under Dual Silver/Organocatalysis

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dc.contributor.author Martínez-Pardo, Pablo
dc.contributor.author Blay Llinares, Gonzalo
dc.contributor.author Vila Descals, Carlos
dc.contributor.author Sanz Marco, Amparo
dc.contributor.author Muñoz, M. Carmen
dc.contributor.author Pedro, José Ramón
dc.date.accessioned 2020-09-29T16:31:58Z
dc.date.available 2020-09-29T16:31:58Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/10550/75689
dc.description.abstract The first enantioselective formal [3 + 2] cycloaddition between α-isocyanoesters and trifluoromethylketones to give 5-trifluoromethyl-2-oxazolines bearing two contiguous stereogenic centers, one of them being a quaternary stereocenter substituted with a CF3 group, has been developed. The reaction is based upon a multicatalytic approach that combines a bifunctional Brønsted base-squaramide organocatalyst and Ag+ as Lewis acid. The reaction could be achieved with a range of aryl and heteroaryl trifluoromethyl ketones, and the resulting oxazolines were obtained with good to excellent diastereo- and enantioselectivity.
dc.language.iso eng
dc.relation.ispartof Journal of Organic Chemistry, 2019, vol. 84, p. 314-325
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Martínez-Pardo, Pablo Blay Llinares, Gonzalo Vila Descals, Carlos Sanz Marco, Amparo Muñoz, M. Carmen Pedro, José Ramón 2019 Enantioselective Synthesis of 5‑Trifluoromethyl-2-oxazolines under Dual Silver/Organocatalysis Journal of Organic Chemistry 84 314 325
dc.subject Química orgànica
dc.subject Catàlisi
dc.title Enantioselective Synthesis of 5‑Trifluoromethyl-2-oxazolines under Dual Silver/Organocatalysis
dc.type info:eu-repo/semantics/article
dc.date.updated 2020-09-29T16:31:59Z
dc.identifier.doi https://doi.org/10.1021/acs.joc.8b02808
dc.identifier.idgrec 129211

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