Copper-catalysed enantioselective Michael addition of malonic esters to β-trifluoromethyl-α,β-unsaturated imines
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Copper-catalysed enantioselective Michael addition of malonic esters to β-trifluoromethyl-α,β-unsaturated imines

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Copper-catalysed enantioselective Michael addition of malonic esters to β-trifluoromethyl-α,β-unsaturated imines

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dc.contributor.author Espinosa López, Miguel
dc.contributor.author Herrera, Jorge
dc.contributor.author Blay Llinares, Gonzalo
dc.contributor.author Cardona Prósper, María Luz
dc.contributor.author Muñoz, M. Carmen
dc.contributor.author Pedro, José Ramón
dc.date.accessioned 2020-09-29T13:54:58Z
dc.date.available 2020-09-29T13:54:58Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/10550/75683
dc.description.abstract Copper triflate-BOX complexes catalyse the enantioselective conjugate addition of methyl malonate to β-trifluoromethyl-α,β-unsaturated imines to give the corresponding enamines bearing a trifluoromethylated stereogenic centre with good yields, and diastereo- and enantioselectivities. The usefulness of the method has been shown with the synthesis of optically active β-trifluoromethyl δ-amino esters and optically active trifluoromethylpiperidones.
dc.language.iso eng
dc.relation.ispartof Organic & Biomolecular Chemistry, 2017, vol. 15, p. 3849-3853
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Espinosa López, Miguel Herrera, Jorge Blay Llinares, Gonzalo Cardona Prósper, María Luz Muñoz, M. Carmen Pedro, José Ramón 2017 Copper-catalysed enantioselective Michael addition of malonic esters to β-trifluoromethyl-α,β-unsaturated imines Organic & Biomolecular Chemistry 15 3849 3853
dc.subject Química orgànica
dc.subject Catàlisi
dc.title Copper-catalysed enantioselective Michael addition of malonic esters to β-trifluoromethyl-α,β-unsaturated imines
dc.type info:eu-repo/semantics/article
dc.date.updated 2020-09-29T13:54:58Z
dc.identifier.doi https://doi.org/10.1039/C7OB00595D
dc.identifier.idgrec 117521

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