Enantioselective synthesis of chiral oxazolines from unactivated ketones and isocyanoacetate esters by synergistic silver/organocatalysis
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Enantioselective synthesis of chiral oxazolines from unactivated ketones and isocyanoacetate esters by synergistic silver/organocatalysis

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Enantioselective synthesis of chiral oxazolines from unactivated ketones and isocyanoacetate esters by synergistic silver/organocatalysis

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dc.contributor.author Martínez-Pardo, Pablo
dc.contributor.author Blay Llinares, Gonzalo
dc.contributor.author Muñoz, M. Carmen
dc.contributor.author Pedro, José Ramón
dc.contributor.author Sanz Marco, Amparo
dc.contributor.author Vila Descals, Carlos
dc.date.accessioned 2020-09-28T14:16:05Z
dc.date.available 2020-09-28T14:16:05Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/10550/75670
dc.description.abstract A multicatalytic approach that combines a bifunctional Brønsted base-squaramide organocatalyst and Ag+ as Lewis acid has been applied in the reaction of unactivated ketones with tert-butyl isocyanoacetate to give chiral oxazolines bearing a quaternary stereocenter. The formal [3+2] cycloaddition provided high yields of the corresponding cis-oxazolines with good diastereoselectivity and excellent enantioselectivity, being applied to aryl-alkyl and alkyl-alkyl ketones.
dc.language.iso eng
dc.relation.ispartof Chemical Communications, 2018, vol. 54, p. 2862-2865
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Martínez-Pardo, Pablo Blay Llinares, Gonzalo Muñoz, M. Carmen Pedro, José Ramón Sanz Marco, Amparo Vila Descals, Carlos 2018 Enantioselective synthesis of chiral oxazolines from unactivated ketones and isocyanoacetate esters by synergistic silver/organocatalysis Chemical Communications 54 2862 2865
dc.subject Catàlisi
dc.subject Química orgànica
dc.title Enantioselective synthesis of chiral oxazolines from unactivated ketones and isocyanoacetate esters by synergistic silver/organocatalysis
dc.type info:eu-repo/semantics/article
dc.date.updated 2020-09-28T14:16:05Z
dc.identifier.doi https://doi.org/10.1039/C8CC00856F
dc.identifier.idgrec 124130

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