Enantioselective synthesis of chiral oxazolines from unactivated ketones and isocyanoacetate esters by synergistic silver/organocatalysis

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Enantioselective synthesis of chiral oxazolines from unactivated ketones and isocyanoacetate esters by synergistic silver/organocatalysis

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	Martínez-Pardo, Pablo; Blay Llinares, Gonzalo Perfil; Muñoz, M. Carmen; Pedro, José Ramón; Sanz Marco, Amparo; Vila Descals, Carlos
	This document is a artículoDate2018
	A multicatalytic approach that combines a bifunctional Brønsted base-squaramide organocatalyst and Ag+ as Lewis acid has been applied in the reaction of unactivated ketones with tert-butyl isocyanoacetate to give chiral oxazolines bearing a quaternary stereocenter. The formal [3+2] cycloaddition provided high yields of the corresponding cis-oxazolines with good diastereoselectivity and excellent enantioselectivity, being applied to aryl-alkyl and alkyl-alkyl ketones.
	Martínez-Pardo, Pablo Blay Llinares, Gonzalo Muñoz, M. Carmen Pedro, José Ramón Sanz Marco, Amparo Vila Descals, Carlos 2018 Enantioselective synthesis of chiral oxazolines from unactivated ketones and isocyanoacetate esters by synergistic silver/organocatalysis Chemical Communications 54 2862 2865
	https://doi.org/10.1039/C8CC00856F

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