Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol
NAGIOS: RODERIC FUNCIONANDO

Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol

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Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol

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dc.contributor.author Dahlgren, David
dc.contributor.author Cano Cebrián, María José
dc.contributor.author Hellström, Per M.
dc.contributor.author Wanders, Alkwin
dc.contributor.author Sjöblom, Markus
dc.contributor.author Lennernäs, Hans
dc.date.accessioned 2020-09-28T13:43:39Z
dc.date.available 2020-09-28T13:43:39Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/10550/75669
dc.description.abstract A healthy intestinal barrier prevents uptake of allergens and toxins, whereas intestinal permeability increases following chemotherapy and in many gastrointestinal and systemic diseases and disorders. Currently, there are no approved drugs that target and repair the intestinal epithelial barrier while there is a medical need for such treatment in gastrointestinal and related conditions. The objective of this single-pass intestinal perfusion study in rats was to investigate the preventive cytoprotective effect of three mucosal protective drugs¿melatonin, misoprostol, and teduglutide¿with different mechanisms of action on an acute jejunal injury induced by exposing the intestine for 15 min to the anionic surfactant, sodium dodecyl sulfate (SDS). The effect was evaluated by monitoring intestinal clearance of 51Cr-labeled ethylenediaminetetraacetate and intestinal histology before, during, and after luminal exposure to SDS. Our results showed that separate pharmacological pretreatments with luminal misoprostol and melatonin reduced acute SDS-induced intestinal injury by 47% and 58%, respectively, while their use in combination abolished this injury. This data supports further development of drug combinations for oral treatments of conditions and disorders related to a dysregulated or compromised mucosal epithelial barrier.
dc.language.iso eng
dc.relation.ispartof International Journal Of Molecular Sciences, 2020, vol. 21, num. 6771
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Dahlgren, David Cano Cebrián, María José Hellström, Per M. Wanders, Alkwin Sjöblom, Markus Lennernäs, Hans 2020 Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol International Journal Of Molecular Sciences 21 6771
dc.subject Absorció intestinal
dc.subject Farmacologia
dc.title Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol
dc.type info:eu-repo/semantics/article
dc.date.updated 2020-09-28T13:43:39Z
dc.identifier.doi https://doi.org/10.3390/ijms21186771
dc.identifier.idgrec 140564

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