Cubic Microcontainers Improve In Situ Colonic Mucoadhesion and Absorption of Amoxicillin in Rats
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Cubic Microcontainers Improve In Situ Colonic Mucoadhesion and Absorption of Amoxicillin in Rats

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Cubic Microcontainers Improve In Situ Colonic Mucoadhesion and Absorption of Amoxicillin in Rats

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dc.contributor.author Christfort, Juliane F.
dc.contributor.author Guillot García, Antonio José
dc.contributor.author Melero Zaera, Ana
dc.contributor.author Thamdrup, Lasse H. E.
dc.contributor.author Garrigues Pelufo, Teresa María
dc.contributor.author Boisen, Anja
dc.contributor.author Zór, Kinga
dc.contributor.author Nielsen, Line H.
dc.date.accessioned 2020-05-15T09:22:06Z
dc.date.available 2020-05-15T09:22:06Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/10550/74624
dc.description.abstract An increased interest in colonic drug delivery has led to a higher focus on the design of delivery devices targeting this part of the gastrointestinal tract. Microcontainers have previously facilitated an increase in oral bioavailability of drugs. The surface texture and shape of microcontainers have proven to influence the mucoadhesion ex vivo. In the present work, these findings were further investigated using an in situ closed-loop perfusion technique in the rat colon, which allowed for simultaneous evaluation of mucoadhesion of the microcontainers as well as drug absorption. Cylindrical, triangular and cubic microcontainers, with the same exterior surface area, were evaluated based on in vitro release, in situ mucoadhesion and in situ absorption of amoxicillin. Additionally, the mucoadhesion of empty cylindrical microcontainers with and without pillars on the top surface was investigated. From the microscopy analysis of the colon sections after the in situ study, it was evident that a significantly higher percentage of cubic microcontainers than cylindrical microcontainers adhered to the intestinal mucus. Furthermore, the absorption rate constants and blood samples indicated that amoxicillin in cubic microcontainers was absorbed more readily than when cylindrical or triangular microcontainers were dosed. This could be due to a higher degree of mucoadhesion for these particular microcontainers.
dc.language.iso eng
dc.relation.ispartof Pharmaceutics, 2020, vol. 12, num. 355
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Christfort, Juliane F. Guillot García, Antonio José Melero Zaera, Ana Thamdrup, Lasse H. E. Garrigues Pelufo, Teresa María Boisen, Anja Zór, Kinga Nielsen, Line H. 2020 Cubic Microcontainers Improve In Situ Colonic Mucoadhesion and Absorption of Amoxicillin in Rats Pharmaceutics 12 355
dc.subject Drogues
dc.subject Absorció intestinal
dc.subject Tecnologia farmacèutica
dc.title Cubic Microcontainers Improve In Situ Colonic Mucoadhesion and Absorption of Amoxicillin in Rats
dc.type info:eu-repo/semantics/article
dc.date.updated 2020-05-15T09:22:06Z
dc.identifier.doi https://doi.org/10.3390/pharmaceutics12040355
dc.identifier.idgrec 138115

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