Social defeat stress: Mechanisms underlying the increase in rewarding effects of drugs of abuse
NAGIOS: RODERIC FUNCIONANDO

Social defeat stress: Mechanisms underlying the increase in rewarding effects of drugs of abuse

DSpace Repository

Social defeat stress: Mechanisms underlying the increase in rewarding effects of drugs of abuse

Show simple item record

dc.contributor.author Montagud Romero, Sandra
dc.contributor.author Blanco Gandía, María del Carmen
dc.contributor.author Reguilón, Marina D.
dc.contributor.author Ferrer Pérez, Carmen
dc.contributor.author Ballestín Hinojosa, Raúl
dc.contributor.author Rodríguez Arias, Marta
dc.contributor.author Miñarro López, José
dc.date.accessioned 2020-04-28T15:46:54Z
dc.date.available 2020-04-28T15:46:54Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/10550/74106
dc.description.abstract Social interaction is known to be the main source of stress in human beings, which explains the translational importance of this research in animals. Evidence reported over the last decade has revealed that, when exposed to social defeat experiences (brief episodes of social confrontations during adolescence and adulthood), the rodent brain undergoes remodeling and functional modifications, which in turn lead to an increase in the rewarding and reinstating effects of different drugs of abuse. The mechanisms by which social stress cause changes in the brain and behavior are unknown, and so the objective of this review is to contemplate how social defeat stress induces long-lasting consequences that modify the reward system. First of all, we will describe the most characteristic results of the short- and long-term consequences of social defeat stress on the rewarding effects of drugs of abuse such as psychostimulants and alcohol. Secondly, and throughout the review, we will carefully assess the neurobiological mechanisms underlying these effects, including changes in the dopaminergic system, corticotrophin releasing factor signaling, epigenetic modifications and the neuroinflammatory response. To conclude, we will consider the advantages and disadvantages and the translational value of the social defeat stress model, and will discuss challenges and future directions.
dc.language.iso eng
dc.relation.ispartof European Journal of Neuroscience, 2018, vol. 48, num. 9, p. 2948-2970
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Montagud Romero, Sandra Blanco Gandía, María del Carmen Reguilón, Marina D. Ferrer Pérez, Carmen Ballestín Hinojosa, Raúl Rodríguez Arias, Marta Miñarro López, José 2018 Social defeat stress: Mechanisms underlying the increase in rewarding effects of drugs of abuse European Journal of Neuroscience 48 9 2948 2970
dc.subject Psicobiologia
dc.title Social defeat stress: Mechanisms underlying the increase in rewarding effects of drugs of abuse
dc.type info:eu-repo/semantics/article
dc.date.updated 2020-04-28T15:46:55Z
dc.identifier.doi https://doi.org/10.1111/ejn.14127
dc.identifier.idgrec 127071

View       (1.043Mb)

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search

Browse

Statistics