Organocatalytic Enantioselective Synthesis of α-Hydroxyketones through a Friedel−Crafts Reaction of Naphthols and Activated Phenols with Aryl- and Alkylglyoxal Hydrates
NAGIOS: RODERIC FUNCIONANDO

Organocatalytic Enantioselective Synthesis of α-Hydroxyketones through a Friedel−Crafts Reaction of Naphthols and Activated Phenols with Aryl- and Alkylglyoxal Hydrates

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Organocatalytic Enantioselective Synthesis of α-Hydroxyketones through a Friedel−Crafts Reaction of Naphthols and Activated Phenols with Aryl- and Alkylglyoxal Hydrates

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dc.contributor.author Vila Descals, Carlos
dc.contributor.author Quintero, Lucía
dc.contributor.author Blay Llinares, Gonzalo
dc.contributor.author Muñoz, M. Carmen
dc.contributor.author Pedro, José Ramón
dc.date.accessioned 2020-04-01T11:07:42Z
dc.date.available 2020-04-01T11:07:42Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/10550/73734
dc.description.abstract An efficient organocatalytic asymmetric synthesis of α-hydroxyketones has been developed. Quinine-derived thiourea catalyzed the enantioselective Friedel−Crafts alkylation of naphthols and activated phenols with aryl- and alkylglyoxal hydrates, providing the corresponding chiral α-hydroxyketones with high yields (up to 97%) and excellent enantioselectivities (up to 99% ee).
dc.language.iso eng
dc.relation.ispartof Organic Letters, 2016, vol. 18, p. 5652-5655
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Vila Descals, Carlos Quintero, Lucía Blay Llinares, Gonzalo Muñoz, M. Carmen Pedro, José Ramón 2016 Organocatalytic Enantioselective Synthesis of α-Hydroxyketones through a Friedel−Crafts Reaction of Naphthols and Activated Phenols with Aryl- and Alkylglyoxal Hydrates Organic Letters 18 5652 5655
dc.subject Química orgànica
dc.subject Reaccions químiques
dc.subject Catàlisi
dc.title Organocatalytic Enantioselective Synthesis of α-Hydroxyketones through a Friedel−Crafts Reaction of Naphthols and Activated Phenols with Aryl- and Alkylglyoxal Hydrates
dc.type info:eu-repo/semantics/article
dc.date.updated 2020-04-01T11:07:42Z
dc.identifier.doi https://doi.org/10.1021/acs.orglett.6b02893
dc.identifier.idgrec 114376

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