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Catalytic Enantioselective Aza-Reformatsky Reaction with Cyclic Imines

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Catalytic Enantioselective Aza-Reformatsky Reaction with Cyclic Imines

dc.contributor.author	De Munck, Lode
dc.contributor.author	Vila Descals, Carlos
dc.contributor.author	Muñoz, M. Carmen
dc.contributor.author	Pedro, José Ramón
dc.date.accessioned	2020-03-30T09:55:06Z
dc.date.available	2020-03-30T09:55:06Z
dc.date.issued	2016
dc.identifier.uri	https://hdl.handle.net/10550/73709
dc.description.abstract	A catalytic highly enantioselective aza‐Reformatsky reaction with cyclic aldimines and ketimines for the synthesis of chiral β‐amino esters with good yields and excellent enantioselectivities is reported. A readily available diaryl prolinol is used as a chiral ligand, ZnMe2 as a zinc source and ethyl iodoacetate as reagent in the presence of air atmosphere. The reaction with cyclic ketimines generates a quaternary stereocenter with excellent levels of enantioselectivity. Furthermore, five‐membered N‐sulfonyl ketimines were used as electrophiles with good enantiomeric excesses, under the optimized reaction conditions. Moreover, several chemical transformations were performed with the chiral β‐amino esters.
dc.language.iso	eng
dc.relation.ispartof	Chemistry-A European Journal, 2016, vol. 22, p. 17590-17594
dc.source	De Munck, Lode Vila Descals, Carlos Muñoz, M. Carmen Pedro, José Ramón 2016 Catalytic Enantioselective Aza-Reformatsky Reaction with Cyclic Imines Chemistry-A European Journal 22 17590 17594
dc.subject	Química orgànica
dc.subject	Reaccions químiques
dc.subject	Catàlisi
dc.title	Catalytic Enantioselective Aza-Reformatsky Reaction with Cyclic Imines
dc.type	journal article	es_ES
dc.date.updated	2020-03-30T09:55:06Z
dc.identifier.doi	https://doi.org/10.1002/chem.201604606
dc.identifier.idgrec	114574
dc.rights.accessRights	open access	es_ES