Catalytic Enantioselective Aza-Reformatsky Reaction with Cyclic Imines
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Catalytic Enantioselective Aza-Reformatsky Reaction with Cyclic Imines

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Catalytic Enantioselective Aza-Reformatsky Reaction with Cyclic Imines

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dc.contributor.author De Munck, Lode
dc.contributor.author Vila Descals, Carlos
dc.contributor.author Muñoz, M. Carmen
dc.contributor.author Pedro, José Ramón
dc.date.accessioned 2020-03-30T09:55:06Z
dc.date.available 2020-03-30T09:55:06Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/10550/73709
dc.description.abstract A catalytic highly enantioselective aza‐Reformatsky reaction with cyclic aldimines and ketimines for the synthesis of chiral β‐amino esters with good yields and excellent enantioselectivities is reported. A readily available diaryl prolinol is used as a chiral ligand, ZnMe2 as a zinc source and ethyl iodoacetate as reagent in the presence of air atmosphere. The reaction with cyclic ketimines generates a quaternary stereocenter with excellent levels of enantioselectivity. Furthermore, five‐membered N‐sulfonyl ketimines were used as electrophiles with good enantiomeric excesses, under the optimized reaction conditions. Moreover, several chemical transformations were performed with the chiral β‐amino esters.
dc.language.iso eng
dc.relation.ispartof Chemistry-A European Journal, 2016, vol. 22, p. 17590-17594
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source De Munck, Lode Vila Descals, Carlos Muñoz, M. Carmen Pedro, José Ramón 2016 Catalytic Enantioselective Aza-Reformatsky Reaction with Cyclic Imines Chemistry-A European Journal 22 17590 17594
dc.subject Química orgànica
dc.subject Reaccions químiques
dc.subject Catàlisi
dc.title Catalytic Enantioselective Aza-Reformatsky Reaction with Cyclic Imines
dc.type info:eu-repo/semantics/article
dc.date.updated 2020-03-30T09:55:06Z
dc.identifier.doi https://doi.org/10.1002/chem.201604606
dc.identifier.idgrec 114574

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