NAGIOS: RODERIC FUNCIONANDO
Organocatalytic Asymmetric Addition of Naphthols and Electron-Rich Phenols to Isatin-Derived Ketimines: Highly Enantioselective Construction of Tetrasubstituted Stereocenters
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Organocatalytic Asymmetric Addition of Naphthols and Electron-Rich Phenols to Isatin-Derived Ketimines: Highly Enantioselective Construction of Tetrasubstituted Stereocenters
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| Montesinos Magraner, Marc; Vila Descals, Carlos; Cantón, Rubén; Blay Llinares, Gonzalo Perfil; Fernández Picot, Isabel; Muñoz, M. Carmen; Pedro, José Ramón | |
| This document is a artículoDate2015 | |
| A quinine-derived thiourea organocatalyst promoted the highly enantioselective addition of naphthols and activated phenols to ketimines derived from isatins. The reaction afforded chiral 3-amino-2-oxindoles with a quaternary stereocenter in high yields (up to 99%) with excellent enantioselectivity (up to 99% ee). To the best of our knowledge, this transformation is the first highly enantioselective addition of naphthols to ketimines. | |
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Montesinos Magraner, Marc Vila Descals, Carlos Cantón, Rubén Blay Llinares, Gonzalo Fernández Picot, Isabel Muñoz, M. Carmen Pedro, José Ramón 2015 Organocatalytic Asymmetric Addition of Naphthols and Electron-Rich Phenols to Isatin-Derived Ketimines: Highly Enantioselective Construction of Tetrasubstituted Stereocenters Angewandte Chemie 54 6320 6324 |
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| https://doi.org/10.1002/anie.201501273 |
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