Organocatalytic Enantioselective Synthesis of Pyrazoles Bearing a Quaternary Stereocenter
NAGIOS: RODERIC FUNCIONANDO

Organocatalytic Enantioselective Synthesis of Pyrazoles Bearing a Quaternary Stereocenter

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Organocatalytic Enantioselective Synthesis of Pyrazoles Bearing a Quaternary Stereocenter

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Vila Descals, Carlos; Amr, Fares Ibrahim; Blay Llinares, Gonzalo Perfil; Muñoz, M. Carmen; Pedro, José Ramón
This document is a artículoDate2016
An efficient one‐pot asymmetric synthesis of pyrazoles bearing a chiral quaternary stereocenter has been developed. Quinine‐derived thiourea catalyzed the enantioselective addition of pyrazolones to isatin‐derived ketimines, providing the corresponding acetylated pyrazoles after in situ treatment with Ac2O/Et3N. The corresponding pyrazoles were afforded in high yields and excellent enantioselectivities.

    Vila Descals, Carlos Amr, Fares Ibrahim Blay Llinares, Gonzalo Muñoz, M. Carmen Pedro, José Ramón 2016 Organocatalytic Enantioselective Synthesis of Pyrazoles Bearing a Quaternary Stereocenter Chemistry-An Asian Journal 11 10 1532 1536
https://doi.org/10.1002/asia.201600325

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