Organocatalytic Enantioselective Alkylation of Pyrazol-3-ones with Isatin-Derived Ketimines: Stereocontrolled Construction of Vicinal Tetrasubstituted Stereocenters

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Organocatalytic Enantioselective Alkylation of Pyrazol-3-ones with Isatin-Derived Ketimines: Stereocontrolled Construction of Vicinal Tetrasubstituted Stereocenters

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	Amr, Fares Ibrahim; Vila Descals, Carlos; Blay Llinares, Gonzalo Perfil; Muñoz, M. Carmen; Pedro, José Ramón
	This document is a artículoDate2016
	A quinine‐derived thiourea catalysed the enantioselective addition of 4‐substituted pyrazolones to isatin‐derived ketimines, providing a variety of aminooxindole‐pyrazolone adducts containing congested vicinal tetrasubstituted stereocentres with excellent outcomes (up to 98% yield, >20:1 dr and 98% ee).
	Amr, Fares Ibrahim Vila Descals, Carlos Blay Llinares, Gonzalo Muñoz, M. Carmen Pedro, José Ramón 2016 Organocatalytic Enantioselective Alkylation of Pyrazol-3-ones with Isatin-Derived Ketimines: Stereocontrolled Construction of Vicinal Tetrasubstituted Stereocenters Advanced Synthesis & Catalysis 358 10 1583 1588
	https://doi.org/10.1002/adsc.201600036

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