Diarylprolinol as a Ligand for Enantioselective Alkynylation of Cyclic Imines
NAGIOS: RODERIC FUNCIONANDO

Diarylprolinol as a Ligand for Enantioselective Alkynylation of Cyclic Imines

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Diarylprolinol as a Ligand for Enantioselective Alkynylation of Cyclic Imines

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De Munck, Lode; Monleón Ventura, Alicia; Vila Descals, Carlos; Pedro, José Ramón
This document is a artículoDate2017
An easily accessible prolinol derived ligand, (S)‐bis(3,5‐bis(trifluoromethyl)phenyl)(pyrrolidin‐2‐yl)methanol, has been efficiently applied in the catalytic enantioselective addition of terminal alkynes to cyclic imines using dimethylzinc (Me2Zn) under mild reaction conditions. The developed catalytic system led to chiral propargylic sulfamidates with high yields (up to 97%) and excellent enantioselectivities (up to 97% ee).

    De Munck, Lode Monleón Ventura, Alicia Vila Descals, Carlos Pedro, José Ramón 2017 Diarylprolinol as a Ligand for Enantioselective Alkynylation of Cyclic Imines Advanced Synthesis & Catalysis 359 9 1582 1587
https://doi.org/10.1002/adsc.201601379

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