Organocatalytic Enantioselective Functionalization of Hydroxyquinolines through an aza-Friedel-Crafts Alkylation with Isatin-derived Ketimines
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Organocatalytic Enantioselective Functionalization of Hydroxyquinolines through an aza-Friedel-Crafts Alkylation with Isatin-derived Ketimines

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Organocatalytic Enantioselective Functionalization of Hydroxyquinolines through an aza-Friedel-Crafts Alkylation with Isatin-derived Ketimines

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dc.contributor.author Vila Descals, Carlos
dc.contributor.author Rendón-Patiño, Alejandra
dc.contributor.author Montesinos Magraner, Marc
dc.contributor.author Blay Llinares, Gonzalo
dc.contributor.author Muñoz, M. Carmen
dc.contributor.author Pedro, José Ramón
dc.date.accessioned 2020-03-27T10:18:22Z
dc.date.available 2020-03-27T10:18:22Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/10550/73683
dc.description.abstract A highly enantioselective addition o hydroxyquinolines to isatin-derived ketimines hasbeen realized using a quinine-derived thiourea organocatalyst. The reaction affords chiral 3-amino-2-oxindoles bearing a quinoline moiety with a quaternary stereocenter in high yields (up to 98%) and excellent enantioselectivities (up to 99%). Moreover, we can extend this methodology for the enantioselective functionalization of 5-hydroxyisoquinoline. This methodology represents, to the best of our knowledge, the first enantioselective addition of hydroxyquinolines to imines.
dc.language.iso eng
dc.relation.ispartof Advanced Synthesis & Catalysis, 2018, vol. 360, num. 5, p. 859-864
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Vila Descals, Carlos Rendón-Patiño, Alejandra Montesinos Magraner, Marc Blay Llinares, Gonzalo Muñoz, M. Carmen Pedro, José Ramón 2018 Organocatalytic Enantioselective Functionalization of Hydroxyquinolines through an aza-Friedel-Crafts Alkylation with Isatin-derived Ketimines Advanced Synthesis & Catalysis 360 5 859 864
dc.subject Reaccions químiques
dc.subject Catàlisi
dc.title Organocatalytic Enantioselective Functionalization of Hydroxyquinolines through an aza-Friedel-Crafts Alkylation with Isatin-derived Ketimines
dc.type info:eu-repo/semantics/article
dc.date.updated 2020-03-27T10:18:22Z
dc.identifier.doi https://doi.org/10.1002/adsc.201701217
dc.identifier.idgrec 121641

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