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Catalytic enantioselective aza-Reformatsky reaction with seven-membered cyclic imines dibenzo[b,f][1,4]oxazepines

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Catalytic enantioselective aza-Reformatsky reaction with seven-membered cyclic imines dibenzo[b,f][1,4]oxazepines

dc.contributor.author	De Munck, Lode
dc.contributor.author	Sukowski, Verena
dc.contributor.author	Vila Descals, Carlos
dc.contributor.author	Muñoz, M. Carmen
dc.contributor.author	Pedro, José Ramón
dc.date.accessioned	2020-03-26T12:56:25Z
dc.date.available	2020-03-26T12:56:25Z
dc.date.issued	2017
dc.identifier.uri	https://hdl.handle.net/10550/73673
dc.description.abstract	A catalytic enantioselective aza-Reformatsky reaction is reported with cyclic dibenzo[b,f][1,4]oxazepines and ethyl iodoacetate leading to the synthesis of chiral ethyl 2-(10,11-dihydrodibenzo[b,f][1,4]oxazepin-11-yl)acetate derivatives with excellent yields and high enantioselectivities (up to 98% yield and 97 : 3 er) using a readily available diaryl prolinol L4 as the chiral ligand and Me2Zn as the zinc source under an air atmosphere. Furthermore, different transformations were carried out with the corresponding chiral β-amino esters, preserving in all cases the optical purity.
dc.language.iso	eng
dc.relation.ispartof	Organic Chemistry Frontiers, 2017, vol. 4, num. 8, p. 1624-1628
dc.source	De Munck, Lode Sukowski, Verena Vila Descals, Carlos Muñoz, M. Carmen Pedro, José Ramón 2017 Catalytic enantioselective aza-Reformatsky reaction with seven-membered cyclic imines dibenzo[b,f][1,4]oxazepines Organic Chemistry Frontiers 4 8 1624 1628
dc.subject	Química orgànica
dc.subject	Reaccions químiques
dc.title	Catalytic enantioselective aza-Reformatsky reaction with seven-membered cyclic imines dibenzo[b,f][1,4]oxazepines
dc.type	journal article	es_ES
dc.date.updated	2020-03-26T12:56:25Z
dc.identifier.doi	https://doi.org/10.1039/C7QO00329C
dc.identifier.idgrec	120299
dc.rights.accessRights	open access	es_ES