Organocatalytic Enantioselective Aminoalkylation of Pyrazol-3-ones with Aldimines Generated in Situ from α‐Amido Sulfones
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Organocatalytic Enantioselective Aminoalkylation of Pyrazol-3-ones with Aldimines Generated in Situ from α‐Amido Sulfones

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Organocatalytic Enantioselective Aminoalkylation of Pyrazol-3-ones with Aldimines Generated in Situ from α‐Amido Sulfones

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dc.contributor.author Carceller-Ferrer, Laura
dc.contributor.author Vila Descals, Carlos
dc.contributor.author Blay Llinares, Gonzalo
dc.contributor.author Fernández Picot, Isabel
dc.contributor.author Muñoz, M. Carmen
dc.contributor.author Pedro, José Ramón
dc.date.accessioned 2020-03-26T12:04:22Z
dc.date.available 2020-11-06T05:45:05Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/10550/73671
dc.description.abstract Herein, an efficient asymmetric aminoalkylation of pyrazolones with α-amido sulfones catalyzed by a quinine-derived squaramide in dichloromethane/aqueous media has been established. A variety of chiral amines were obtained with high yields (up to 98%) and excellent enantioselectivities (up to 99% ee). The corresponding products are transformed into optically active acetylated pyrazoles after treatment with Ac2O/Et3N, because of the instability of some adducts. The reaction tolerates a wide range of α-amido sulfones and different pyrazolones.
dc.language.iso eng
dc.relation.ispartof Organic & Biomolecular Chemistry, 2019, vol. 17, num. 46, p. 9859-9863
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Carceller-Ferrer, Laura Vila Descals, Carlos Blay Llinares, Gonzalo Fernández Picot, Isabel Muñoz, M. Carmen Pedro, José Ramón 2019 Organocatalytic Enantioselective Aminoalkylation of Pyrazol-3-ones with Aldimines Generated in Situ from α‐Amido Sulfones Organic & Biomolecular Chemistry 17 46 9859 9863
dc.subject Química orgànica
dc.subject Catàlisi
dc.title Organocatalytic Enantioselective Aminoalkylation of Pyrazol-3-ones with Aldimines Generated in Situ from α‐Amido Sulfones
dc.type info:eu-repo/semantics/article
dc.date.updated 2020-03-26T12:04:22Z
dc.identifier.doi https://doi.org/10.1039/C9OB02252J
dc.identifier.idgrec 135253
dc.embargo.terms 1 year

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