Peri-implant peripheral giant cell lesions : report of 13 new cases and comparative histological and immunohistochemical analysis with peripheral and central giant cell lesions
NAGIOS: RODERIC FUNCIONANDO

Peri-implant peripheral giant cell lesions : report of 13 new cases and comparative histological and immunohistochemical analysis with peripheral and central giant cell lesions

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Peri-implant peripheral giant cell lesions : report of 13 new cases and comparative histological and immunohistochemical analysis with peripheral and central giant cell lesions

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dc.contributor.author Morais, Thayná-Melo-de Lima es
dc.contributor.author Soares, Ciro Dantas es
dc.contributor.author Aguirre Urízar, José Manuel es
dc.contributor.author Alberdi Navarro, Javier es
dc.contributor.author Almeida, Oslei Paes de es
dc.contributor.author Pires, Fábio-Ramôa es
dc.date.accessioned 2020-02-05T11:21:41Z
dc.date.available 2020-02-05T11:21:41Z
dc.date.issued 2019 es
dc.identifier.uri https://hdl.handle.net/10550/72932
dc.description.abstract Few cases or peri-implant peripheral giant cell lesions (PGCL) have been reported in the literature. The aim of this study was to report 13 new cases of peri-implant PGCL and compare the expression of smooth muscle actin, Bcl-2 protein, GLUT-1, CD68, osteoprotegerin, receptor activator of nuclear factor kappa-B, Ki-67 and CD34 in these cases with PGCL and central giant cell lesions (CGCL). Clinical data were retrieved from the laboratory records and histological analysis was performed using HE-stained slides. Immunohistochemical reactions for the above mentioned antibodies were performed and digitally scored. Peri-implant PGCL mostly affected the posterior mandible of adult females. CD68 and Bcl-2 expressions were higher in conventional PGCL and CGCL than in peri-implant PGCL (p=0.033 for CD68 and p<.0001 for Bcl-2). Microvessel density was higher in conventional peripheral than in central and peri-implant PGCL (p=0.002). Proliferative index of the mononuclear cells showed no statistically significant differences comparing the three groups but it was higher in peri-implant PGCL. The current study demonstrated that peri-implant PGCL is more common in the posterior mandible of adult females. There were some differences in microvessel density, proliferative activity and expression of CD68 and Bcl-2 among conventional PGCL, peri-implant and CGCL. Further studies are encouraged to better understand these early findings. es
dc.source Morais, Thayná-Melo-de Lima ; Soares, Ciro Dantas ; Aguirre Urízar, José Manuel ; Alberdi Navarro, Javier ; Almeida, Oslei Paes de ; Pires, Fábio-Ramôa. Peri-implant peripheral giant cell lesions : report of 13 new cases and comparative histological and immunohistochemical analysis with peripheral and central giant cell lesions. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 24 6 2019: 2- es
dc.title Peri-implant peripheral giant cell lesions : report of 13 new cases and comparative histological and immunohistochemical analysis with peripheral and central giant cell lesions es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.23088 es

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