Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study
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Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study

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Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study

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dc.contributor.author Domingo-Relloso, A
dc.contributor.author Grau Pérez, María
dc.contributor.author Galan Chilet, Inmaculada
dc.contributor.author Garrido-Martinez, M.J.
dc.contributor.author Tormos, Carmen
dc.contributor.author Navas-Acien, Ana
dc.contributor.author Gómez-Ariza, José LuisL
dc.contributor.author Monzó-Beltran, Lidia
dc.contributor.author Sáez Tormo, Guillermo
dc.contributor.author Garcia-Barrera, Tamara
dc.contributor.author Dueñas Laita, Antonio
dc.contributor.author Briongos Figuero, Laisa S
dc.contributor.author Martin-Escudero, Juan C.
dc.contributor.author Chaves Martínez, Felipe Javier
dc.contributor.author Redón i Más, Josep
dc.contributor.author Tellez-Plaza, Maria
dc.date.accessioned 2020-01-31T09:20:53Z
dc.date.available 2020-01-31T09:20:53Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/10550/72794
dc.description.abstract INTRODUCTION: Few studies have investigated the role of exposure to metals and metal mixtures on oxidative stress in the general population. OBJECTIVES: We evaluated the cross-sectional association of urinary metal and metal mixtures with urinary oxidative stress biomarkers, including oxidized to reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), and 8‑oxo‑7,8‑dihydroguanine (8-oxo-dG), in a representative sample of a general population from Spain (Hortega Study). METHODS: Urine antimony (Sb), barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), molybdenum (Mo), vanadium (V) and zinc (Zn) were measured by ICPMS in 1440 Hortega Study participants. RESULTS: The geometric mean ratios (GMRs) of GSSG/GSH comparing the 80th to the 20th percentiles of metal distributions were 1.15 (95% confidence intervals [95% CI]: 1.03-1.27) for Mo, 1.17 (1.05-1.31) for Ba, 1.23 (1.04-1.46) for Cr and 1.18 (1.00-1.40) for V. For MDA, the corresponding GMRs (95% CI) were 1.13 (1.03-1.24) for Zn and 1.12 (1.02-1.23) for Cd. In 8-oxo-dG models, the corresponding GMR (95% CI) were 1.12 (1.01-1.23) for Zn and 1.09 (0.99-1.20) for Cd. Cr for GSSG/GSH and Zn for MDA and 8-oxo-dG drove most of the observed associations. Principal component (PC) 1 (largely reflecting non-essential metals) was positively associated with GSSG/GSH. The association of PC2 (largely reflecting essential metals) was positive for GSSG/GSH but inverse for MDA. CONCLUSIONS: Urine Ba, Cd, Cr, Mo, V and Zn were positively associated with oxidative stress measures at metal exposure levels relevant for the general population. The potential health consequences of environmental, including nutritional, exposure to these metals warrants further investigation.
dc.language.iso cat
dc.relation.ispartof Environment International, 2019, vol. 123, p. 171-180
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Domingo-Relloso, A Grau Pérez, María Galan Chilet, Inmaculada Garrido-Martinez, M.J. Tormos, Carmen Navas-Acien, Ana Gómez-Ariza, José LuisL Monzó-Beltran, Lidia Sáez Tormo, Guillermo Garcia-Barrera, Tamara Dueñas Laita, Antonio Briongos Figuero, Laisa S Martin-Escudero, Juan C. Chaves Martinez, Felipe Javier Redón, Josep Tellez-Plaza, Maria 2019 Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study Environment International 123 171 180
dc.title Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study
dc.type info:eu-repo/semantics/article
dc.date.updated 2020-01-31T09:20:53Z
dc.identifier.doi https://doi.org/10.1016/j.envint.2018.11.055
dc.identifier.idgrec 130951

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