Homochiral Metal-Organic Frameworks for Enantioselective Separations in Liquid Chromatography
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Homochiral Metal-Organic Frameworks for Enantioselective Separations in Liquid Chromatography

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Homochiral Metal-Organic Frameworks for Enantioselective Separations in Liquid Chromatography

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dc.contributor.author Corella-Ochoa, M. Nieves
dc.contributor.author Tapia, Jesús B.
dc.contributor.author Rubin, Heather N.
dc.contributor.author Lillo, Vanesa
dc.contributor.author González-Cobos, Jesús
dc.contributor.author Núñez-Rico, J. L.
dc.contributor.author Balestra, Salvador R. G.
dc.contributor.author Almora-Barrios, Neyvis
dc.contributor.author Lledós, Marina
dc.contributor.author Güell-Bara, Arnau
dc.contributor.author Cabezas-Giménez, Juanjo
dc.contributor.author Escudero-Adán, Eduardo
dc.contributor.author Vidal-Ferran, Anton
dc.contributor.author Calero, Sofía
dc.contributor.author Reynolds, Melissa
dc.contributor.author Martí Gastaldo, Carlos
dc.contributor.author Galán Mascarós, José Ramón
dc.date.accessioned 2019-11-13T15:10:49Z
dc.date.available 2019-11-19T05:45:05Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/10550/72194
dc.description.abstract Selective separation of enantiomers is a substantial challenge for the pharmaceutical industry. Chromatography on chiral stationary phases is the standard method, but at a very high cost for industrial-scale purification owing to the high cost of the chiral stationary phases. Typically, these materials are poorly robust, expensive to manufacture and often too specific for a single desired substrate, lacking desirable versatility across different chiral analytes. Here we disclose a porous, robust homochiral metal-organic framework (MOF), TAMOF-1, built from copper(II) and an affordable linker prepared from natural L-histidine. TAMOF-1 has shown to be able to separate a variety of model racemic mixtures, including drugs, in a wide range of solvents of different polarity, outperforming several commercial chiral columns for HPLC separations. Although not exploited in the present article, it is worthy to mention that the preparation of this new material is scalable to the multikilogram scale, opening unprecedented possibilities for low-energy chiral separation at the industrial scale.
dc.language.iso eng
dc.relation.ispartof Journal of the American Chemical Society, 2019, vol. 141, num. 36, p. 14306-14316
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Corella-Ochoa, M. Nieves Tapia, Jesús B. Rubin, Heather N. Lillo, Vanesa González-Cobos, Jesús Núñez-Rico, J. L. Balestra, Salvador R. G. Almora-Barrios, Neyvis Lledós, Marina Güell-Bara, Arnau Cabezas-Giménez, Juanjo Escudero-Adán, Eduardo Vidal-Ferran, Anton Calero, Sofía Reynolds, Melissa Martí Gastaldo, Carlos Galán Mascarós, José Ramón 2019 Homochiral Metal-Organic Frameworks for Enantioselective Separations in Liquid Chromatography Journal of the American Chemical Society 141 36 14306 14316
dc.subject Química organometàl·lica
dc.title Homochiral Metal-Organic Frameworks for Enantioselective Separations in Liquid Chromatography
dc.type info:eu-repo/semantics/article
dc.date.updated 2019-11-13T15:10:49Z
dc.identifier.doi https://doi.org/10.1021/jacs.9b06500
dc.identifier.idgrec 135126
dc.accrualMethod
dc.embargo.terms 1 year

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