Epigenetics and periodontics : a systematic review
NAGIOS: RODERIC FUNCIONANDO

Epigenetics and periodontics : a systematic review

DSpace Repository

Epigenetics and periodontics : a systematic review

Show simple item record

dc.contributor.author Almiñana Pastor, Pedro J. es
dc.contributor.author Boronat Catalá, Montserrat es
dc.contributor.author Micó Martínez, Pablo es
dc.contributor.author Bellot Arcís, Carlos es
dc.contributor.author López Roldán, Andrés es
dc.contributor.author Alpiste Illueca, Francisco M. es
dc.date.accessioned 2019-11-06T12:51:53Z
dc.date.available 2019-11-06T12:51:53Z
dc.date.issued 2019 es
dc.identifier.uri https://hdl.handle.net/10550/72068
dc.description.abstract Despite decades of research, our knowledge of several important aspects of periodontal pathogenesis remains incomplete. Epigenetics allows to perform dynamic analysis of different variations in gene expression, providing this great advantage to the static measurement provided by genetic markers. The aim of this systematic review is to analyze the possible relationships between different epigenetic mechanisms and periodontal diseases, and to assess their potential use as biomarkers of periodontitis. A systematic search was conducted in six databases using MeSH and non-MeSH terms. The review fulfilled PRISMA criteria (Preferred Reporting Items for Systematic reviews and Meta-analysis). 36 studies met the inclusion criteria. Due to the heterogeneity of the articles, it was not possible to conduct quantitative analysis. Regarding qualitative synthesis, however, it was found that epigenetic mechanisms may be used as biological markers of periodontal disease, as their dynamism and molecular stability makes them a valuable diagnostic tool. Epigenetic markers alter gene expression, producing either silencing or over-expression of molecular transcription that respond to the demands of the cellular surroundings. Gingival crevicular fluid collection is a non-invasive and simple procedure, which makes it an ideal diagnostic medium for detection of both oral and systemic issues. Although further research is needed, this seems to be a promising field of research in the years to come. es
dc.source Almiñana Pastor, Pedro J. ; Boronat Catalá, Montserrat ; Micó Martínez, Pablo ; Bellot Arcís, Carlos ; López Roldán, Andrés ; Alpiste Illueca, Francisco M.. Epigenetics and periodontics : a systematic review. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 24 5 2019: 10- es
dc.title Epigenetics and periodontics : a systematic review es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.23008 es

View       (433.4Kb)

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search

Browse

Statistics