The telomeric Cdc13-Stn1-Ten1 complex regulates RNA polymerase II transcription
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The telomeric Cdc13-Stn1-Ten1 complex regulates RNA polymerase II transcription

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The telomeric Cdc13-Stn1-Ten1 complex regulates RNA polymerase II transcription

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dc.contributor.author Calvo, Olga
dc.contributor.author Grandin, Nathalie
dc.contributor.author Jordán Plá, Antonio
dc.contributor.author Miñambres, Esperanza
dc.contributor.author González-Polo, Noelia
dc.contributor.author Pérez Ortín, José Enrique
dc.contributor.author Charbonneau, Michel
dc.date.accessioned 2019-07-12T13:15:41Z
dc.date.available 2019-07-12T13:15:41Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/10550/70810
dc.description.abstract Specialized telomeric proteins have an essential role in maintaining genome stability through chromosome end protection and telomere length regulation. In the yeast Saccharomyces cerevisiae, the evolutionary conserved CST complex, composed of the Cdc13, Stn1 and Ten1 proteins, largely contributes to these functions. Here, we report genetic interactions between TEN1 and several genes coding for transcription regulators. Molecular assays confirmed this novel function of Ten1 and further established that it regulates the occupancies of RNA polymerase II and the Spt5 elongation factor within transcribed genes. Since Ten1, but also Cdc13 and Stn1, were found to physically associate with Spt5, we propose that Spt5 represents the target of CST in transcription regulation. Moreover, CST physically associates with Hmo1, previously shown to mediate the architecture of S-phase transcribed genes. The fact that, genomewide, the promoters of genes down-regulated in the ten1-31 mutant are prefentially bound by Hmo1, leads us to propose a potential role for CST in synchronizing transcription with replication fork progression following head-on collisions.
dc.language.iso eng
dc.relation.ispartof Nucleic Acids Research, 2019, vol. 47, num. 12, p. 6250-6268
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Calvo, Olga Grandin, Nathalie Jordán Plá, Antonio Miñambres, Esperanza González-Polo, Noelia Pérez Ortín, José Enrique Charbonneau, Michel 2019 The telomeric Cdc13-Stn1-Ten1 complex regulates RNA polymerase II transcription Nucleic Acids Research 47 12 6250 6268
dc.subject Genomes
dc.subject Cromosomes
dc.title The telomeric Cdc13-Stn1-Ten1 complex regulates RNA polymerase II transcription
dc.type info:eu-repo/semantics/article
dc.date.updated 2019-07-12T13:15:42Z
dc.identifier.doi https://doi.org/10.1093/nar/gkz279
dc.identifier.idgrec 133516

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