Non-muscle myosin II as a predictive factor in head and neck squamous cell carcinoma
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Non-muscle myosin II as a predictive factor in head and neck squamous cell carcinoma

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Non-muscle myosin II as a predictive factor in head and neck squamous cell carcinoma

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dc.contributor.author Dias, Kelly-Bienk es
dc.contributor.author Flores, Anacláudia-Pereira-Costa es
dc.contributor.author Hildebrand, Laura de Campos es
dc.contributor.author Oliveira, Márcia Gaiger de es
dc.contributor.author Lamers, Marcelo-Lazzaron es
dc.contributor.author Rados, Pantelis Varvaki es
dc.contributor.author Magnusson, Alessandra-Selinger es
dc.contributor.author Sant'ana Filho, Manoel es
dc.date.accessioned 2019-07-02T09:55:58Z
dc.date.available 2019-07-02T09:55:58Z
dc.date.issued 2019 es
dc.identifier.uri https://hdl.handle.net/10550/70671
dc.description.abstract The present study attempted to provide information regarding non-muscle myosin II (MII) isoforms immunoreactivity in patients with head and neck squamous cell carcinoma (HNSCC) and analysis of the patients? clinical status after 5 years of monitoring. A semiquantitative analysis of the immunoreactivity of the MII isoforms was performed in 54 surgical specimens and its correlation with clinical and pathological variables and prognosis was verified. Data were analyzed using chi-square, Mann-Whitney and Kruskal-Wallis tests. To evaluate the survival over the total monitoring time and any connection with the proteins studied, the Kaplan-Meier analysis was used. P values ?0.05 were considered statistically significant. In the advanced stages of pathological tumor-node-metastasis, the expression of MIIB in adjacent non-neoplastic epithelial tissues tended to increase (p = 0.057). In tumoral zones there was an association of high expression among the three isoforms (MIIA/MIIB p=0,001, MIIB/MIIC p=0,006 and MIIA/MIIC p=0,012). Negative clinical evolution in patients was directly correlated to increased MIIC expression in the tumoral zone of invasion in HNSCC (p = 0.017). Based on clinical evolution after the monitoring period, patients with tumors expressing MIIC had poorer prognoses (p = 0.048). The present study suggests that MIIB expression in non-neoplastic adjacent epithelial tissues may indicate a potential for regional metastasis and that MIIC expression in the tumoral zone of invasion is predictive of negative evolution of the disease. es
dc.source Dias, Kelly-Bienk ; Flores, Anacláudia-Pereira-Costa ; Hildebrand, Laura de Campos ; Oliveira, Márcia Gaiger de ; Lamers, Marcelo-Lazzaron ; Rados, Pantelis Varvaki ; Magnusson, Alessandra-Selinger ; Sant'ana Filho, Manoel. Non-muscle myosin II as a predictive factor in head and neck squamous cell carcinoma. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 24 3 2019: 7- es
dc.title Non-muscle myosin II as a predictive factor in head and neck squamous cell carcinoma es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.22898 es

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