Digital holographic microscopy as a screening technology for diabetes
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Digital holographic microscopy as a screening technology for diabetes

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Digital holographic microscopy as a screening technology for diabetes

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dc.contributor.author Doblas Expósito, Ana Isabel
dc.contributor.author García Sucerquia, Jorge Iván
dc.contributor.author Saavedra Tortosa, Genaro
dc.contributor.author Martínez Corral, Manuel
dc.date.accessioned 2019-06-18T12:45:25Z
dc.date.available 2019-06-18T12:45:25Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/10550/70496
dc.description.abstract Label-free quantitative phase imaging (QPI) is the hallmark of digital holographic microscopy (DHM). One of the most interesting medical applications of QPI-DHM is that it can be used to analyze illnesses in which the refractive index or/and the morphology of cells/tissues are distorted, from the acquisition of a single image. In this contribution, we obtain the phase maps of red blood cells (RBCs) samples of patients suffering from diabetes mellitus type 1 (DM1) by using a DHM. Our experimental results show that the measured phase values are significantly different between control non-diabetic and diabetic patients. The high correlation coefficient between the phase and the glycated hemoglobin (HbA1C) values determined by the gold standard method to screen diabetes and the clear separation between the two groups indicate that DHM may potentially be used to evaluate long-term glycemic control in diabetic patients as well as to diagnose diabetes.
dc.language.iso eng
dc.relation.ispartof Proceedings of the SPIE, 2019, vol. 10997, p. 1-7
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Doblas Expósito, Ana Isabel García Sucerquia, Jorge Iván Saavedra Tortosa, Genaro Martínez Corral, Manuel 2019 Digital holographic microscopy as a screening technology for diabetes Proceedings of the SPIE 10997 1 7
dc.subject Microscòpia
dc.subject Òptica Aparells i instruments
dc.title Digital holographic microscopy as a screening technology for diabetes
dc.type info:eu-repo/semantics/article
dc.date.updated 2019-06-18T12:45:25Z
dc.identifier.doi https://doi.org/10.1117/12.2523416
dc.identifier.idgrec 133399

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