Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and Drug-Action in Translational Heart Models
NAGIOS: RODERIC FUNCIONANDO

Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and Drug-Action in Translational Heart Models

DSpace Repository

Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and Drug-Action in Translational Heart Models

Show simple item record

dc.contributor.author Lee, Peter
dc.contributor.author Calvo, Conrado J.
dc.contributor.author Alfonso-Almazán, José M.
dc.contributor.author Quintanilla, Jorge G.
dc.contributor.author Chorro Gascó, Francisco Javier
dc.contributor.author Yan, Ping
dc.contributor.author Loew, Leslie M.
dc.contributor.author Filgueiras-Rama, David
dc.contributor.author Millet, José
dc.date.accessioned 2019-06-17T07:10:26Z
dc.date.available 2019-06-17T07:10:26Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/10550/70440
dc.description.abstract Panoramic optical mapping is the primary method for imaging electrophysiological activity from the entire outer surface of Langendorff-perfused hearts. To date, it is the only method of simultaneously measuring multiple key electrophysiological parameters, such as transmembrane voltage and intracellular free calcium, at high spatial and temporal resolution. Despite the impact it has already had on the fields of cardiac arrhythmias and whole-heart computational modeling, present-day system designs precludes its adoption by the broader cardiovascular research community because of their high costs. Taking advantage of recent technological advances, we developed and validated low-cost optical mapping systems for panoramic imaging using Langendorff-perfused pig hearts, a clinically-relevant model in basic research and bioengineering. By significantly lowering financial thresholds, this powerful cardiac electrophysiology imaging modality may gain wider use in research and, even, teaching laboratories, which we substantiated using the lower-cost Langendorff-perfused rabbit heart model.
dc.language.iso cat
dc.relation.ispartof Scientific Reports, 2017, vol. 7, num. 43217, p. 1-14
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Lee, Peter Calvo, Conrado J. Alfonso-Almazán, José M. Quintanilla, Jorge G. Chorro Gascó, Francisco Javier Yan, Ping Loew, Leslie M. Filgueiras-Rama, David Millet, José 2017 Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and Drug-Action in Translational Heart Models Scientific Reports 7 43217 1 14
dc.subject Fisiologia
dc.subject Cor Malalties
dc.subject Bioenginyeria
dc.subject Sistema cardiovascular
dc.subject Diagnòstic per la imatge
dc.title Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and Drug-Action in Translational Heart Models
dc.type info:eu-repo/semantics/article
dc.date.updated 2019-06-17T07:10:26Z
dc.identifier.doi https://doi.org/10.1038/srep43217
dc.identifier.idgrec 133424

View       (3.070Mb)

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search

Browse

Statistics