Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: the ESCARVAL-RISK study
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Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: the ESCARVAL-RISK study

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Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: the ESCARVAL-RISK study

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dc.contributor.author Orozco Beltrán, Domingo
dc.contributor.author Gil Guillen, Vicente F.
dc.contributor.author Redón i Más, Josep
dc.contributor.author Martín Moreno, José María
dc.contributor.author Pallares, Vicente
dc.contributor.author Navarro Pérez, Jorge
dc.contributor.author Valls-Roca, Francisco
dc.contributor.author Sanchis-Domenech, Carlos
dc.contributor.author Fernández-Gimenez, Antonio
dc.contributor.author Perez-Navarro, Ana
dc.contributor.author Bertomeu-Martinez, Vicente
dc.contributor.author Bertomeu-González, Vicente
dc.contributor.author Cordero, Alberto
dc.contributor.author Pascual-de-la-Torre, Manuel
dc.contributor.author Trillo-Mata, Jose Luis
dc.contributor.author Carratalá Munuera, Concepción
dc.contributor.author Pita Fernández, Salvador
dc.contributor.author Uso, Ruth
dc.contributor.author Durazo Arvizu, Ramón
dc.contributor.author Cooper, Richard
dc.contributor.author Sanz, Ginés
dc.contributor.author Castellano, Jose M.
dc.contributor.author Ascaso Gimilio, Juan Francisco
dc.contributor.author Carmena Rodriguez, Rafael
dc.contributor.author Tellez-Plaza, María
dc.contributor.author ESCARVAL Study Group.
dc.date.accessioned 2019-05-24T12:05:17Z
dc.date.available 2019-05-24T12:05:17Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/10550/70294
dc.description.abstract The potential impact of targeting different components of an adverse lipid profile in populations with multiple cardiovascular risk factors is not completely clear. This study aims to assess the association between different components of the standard lipid profile with all cause mortality and hospitalization due to cardiovascular events in a high-risk population. Methods This prospective registry included high risk adults over 30 years old free of cardiovascular disease (2008±2012). Diagnosis of hypertension, dyslipidemia or diabetes mellitus was inclusion criterion. Lipid biomarkers were evaluated. Primary endpoints were all-cause mortality and hospital admission due to coronary heart disease or stroke. We estimated adjusted rate ratios (aRR), absolute risk differences and population attributable risk associated with adverse lipid profiles. Results 51,462 subjects were included with a mean age of 62.6 years (47.6% men). During an average follow-up of 3.2 years, 919 deaths, 1666 hospitalizations for coronary heart disease and 1510 hospitalizations for stroke were recorded. The parameters that showed an increased rate for total mortality, coronary heart disease and stroke hospitalization were, respectively, low HDL-Cholesterol: aRR 1.25, 1.29 and 1.23; high Total/HDL-Cholesterol: aRR 1.22, 1.38 and 1.25; and high Triglycerides/HDL-Cholesterol: aRR 1.21, 1.30, 1.09. The parameters that showed highest population attributable risk (%) were, respectively, low HDL-Cholesterol: 7.70, 11.42, 8.40; high Total/HDL-Cholesterol: 6.55, 12.47, 8.73; and high Triglycerides/ HDL-Cholesterol: 8.94, 15.09, 6.92. Conclusions In a population with cardiovascular risk factors, HDL-cholesterol, Total/HDL-cholesterol and triglycerides/HDL-cholesterol ratios were associated with a higher population attributable risk for cardiovascular disease compared to other common biomarkers.
dc.language.iso eng
dc.relation.ispartof Plos One, 2017, vol. 12, num. 10, p. e0186196 - 1-20
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Orozco Beltrán, Domingo Gil Guillen, Vicente F. Redón i Mas, Josep Martín Moreno, Jose María Pallares, Vicente Navarro Pérez, Jorge Valls-Roca, Francisco Sanchis-Domenech, Carlos Fernández-Gimenez, Antonio Perez-Navarro, Ana Bertomeu-Martinez, Vicente Bertomeu-González, Vicente Cordero, Alberto Pascual-de-la-Torre, Manuel Trillo, Jose L. Carratalá Munuera, Concepción Pita Fernández, Salvador Uso, Ruth Durazo Arvizu, Ramón Cooper, Richard Sanz, Ginés Castellano, Jose M. Ascaso Gimilio, Juan Francisco Carmena Rodriguez, Rafael Tellez-Plaza, María ESCARVAL Study Group. 2017 Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: the ESCARVAL-RISK study Plos One 12 10 e0186196 - 1 20
dc.subject Obesitat
dc.subject Sistema cardiovascular
dc.subject Mortalitat
dc.title Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: the ESCARVAL-RISK study
dc.type info:eu-repo/semantics/article
dc.date.updated 2019-05-24T12:05:17Z
dc.identifier.doi https://doi.org/10.1371/journal.pone.0186196
dc.identifier.idgrec 120838

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