TarSynFlow, a workflow for bacterial genome comparisons that revealed genes putatively involved in the probiotic character of Shewanella putrefaciens strain Pdp11
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TarSynFlow, a workflow for bacterial genome comparisons that revealed genes putatively involved in the probiotic character of Shewanella putrefaciens strain Pdp11

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TarSynFlow, a workflow for bacterial genome comparisons that revealed genes putatively involved in the probiotic character of Shewanella putrefaciens strain Pdp11

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dc.contributor.author Seoane, Pedro
dc.contributor.author Tapia-Paniagua, Silvana T.
dc.contributor.author Bautista, Rocío
dc.contributor.author Alcaide Moreno, Elena
dc.contributor.author Esteve Sánchez, Mª Consuelo
dc.contributor.author Martínez-Manzanares, Eduardo
dc.contributor.author Balebona, M. Carmen
dc.contributor.author Claros, M. Gonzalo
dc.contributor.author Moriñigo, Miguel A.
dc.date.accessioned 2019-04-16T13:01:20Z
dc.date.available 2019-04-16T13:01:20Z
dc.date.issued 2019
dc.identifier.uri http://hdl.handle.net/10550/69991
dc.description.abstract Probiotic microorganisms are of great interest in clinical, livestock and aquaculture. Knowledge of the genomic basis of probiotic characteristics can be a useful tool to understand why some strains can be pathogenic while others are probiotic in the same species. An automatized workflow called TarSynFlow (Targeted Synteny Workflow) has been then developed to compare finished or draft bacterial genomes based on a set of proteins. When used to analyze the finished genome of the probiotic strain Pdp11 of Shewanella putrefaciens and genome drafts from seven known non-probiotic strains of the same species obtained in this work, 15 genes were found exclusive of Pdp11. Their presence was confirmed by PCR using Pdp11-specific primers. Functional inspection of the 15 genes allowed us to hypothesize that Pdp11 underwent genome rearrangements spurred by plasmids and mobile elements. As a result, Pdp11 presents specific proteins for gut colonization, bile salt resistance and gut pathogen adhesion inhibition, which can explain some probiotic features of Pdp11.
dc.language.iso eng
dc.relation.ispartof Peerj, 2019, vol. 7, num. e6526, p. 1-25
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Seoane, Pedro Tapia-Paniagua, Silvana T. Bautista, Rocío Alcaide Moreno, Elena Esteve Sánchez, Mª Consuelo Martínez-Manzanares, Eduardo Balebona, M. Carmen Claros, M. Gonzalo Moriñigo, Miguel A. 2019 TarSynFlow, a workflow for bacterial genome comparisons that revealed genes putatively involved in the probiotic character of Shewanella putrefaciens strain Pdp11 Peerj 7 e6526 1 25
dc.subject Genòmica
dc.subject Microbiologia
dc.title TarSynFlow, a workflow for bacterial genome comparisons that revealed genes putatively involved in the probiotic character of Shewanella putrefaciens strain Pdp11
dc.type info:eu-repo/semantics/article
dc.date.updated 2019-04-16T13:01:21Z
dc.identifier.doi https://doi.org/10.7717/peerj.6526
dc.identifier.idgrec 131273

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