Effectiveness of a spray containing 1% malic acid in patients with xerostomia induced by graft-versus-host disease
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Effectiveness of a spray containing 1% malic acid in patients with xerostomia induced by graft-versus-host disease

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Effectiveness of a spray containing 1% malic acid in patients with xerostomia induced by graft-versus-host disease

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dc.contributor.author Bardellini, Elena es
dc.contributor.author Amadori, Francesca es
dc.contributor.author Conti, Giulio es
dc.contributor.author Veneri, Federica es
dc.contributor.author Majorana, Alessandra es
dc.date.accessioned 2019-04-15T10:50:10Z
dc.date.available 2019-04-15T10:50:10Z
dc.date.issued 2019 es
dc.identifier.uri http://hdl.handle.net/10550/69965
dc.description.abstract To evaluate the clinical effectiveness of a topical sialogogue spray (malic acid, 1%) in the treatment of xerostomia in patients with chronic Graft versus Host Disease (cGVHD). This study was designed as a randomized double-blind clinical study. Twenty-eight patients with cGVHD suffering from xerostomia were divided into 2 groups: the first group (14 patients) received a topical sialagogue spray containing malic acid 1% (SalivAktive®) whereas the second group (14 patients) received a placebo. Both groups received treatment for 2 weeks. Dry Mouth Questionnaire (DMQ) scores and unstimulated salivary flows rate were collected before and after treatment. DMQ scores increased significantly from 1.3 ± 0.4 to 3.5 ± 0.4 points (p <0.05) after two weeks of treatment with malic acid, whereas in the control group DMQ scores increased from 1.2 ± 0.7 points to 1.4 ± 0.6 (p >0.05). The unstimulated salivary flow rate in patients treated with malic acid increased significantly from 0.15 ± 0.06 mL/min to 0.24± 0.08 mL/min, while that of the patients treated with placebo went from 0.16 ± 0.07 mL/min to 0.17 ± 0.09 mL/min (p >0.05). Malic acid 1% spray can be considered effective in the treatment of GVHD induced xerostomia. es
dc.source Bardellini, Elena ; Amadori, Francesca ; Conti, Giulio ; Veneri, Federica ; Majorana, Alessandra. Effectiveness of a spray containing 1% malic acid in patients with xerostomia induced by graft-versus-host disease. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 24 2 2019: 15- es
dc.title Effectiveness of a spray containing 1% malic acid in patients with xerostomia induced by graft-versus-host disease es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.22699 es

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