Biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw : a systematic review
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Biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw : a systematic review

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Biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw : a systematic review

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dc.contributor.author Lorenzo Pouso, A.I. es
dc.contributor.author Pérez-Sayáns, Mario es
dc.contributor.author González Palanca, Sergio es
dc.contributor.author Chamorro Petronacci, Cintia Micaela es
dc.contributor.author Bagán Sebastián, José Vicente es
dc.contributor.author García García, Abel es
dc.date.accessioned 2019-03-07T13:18:59Z
dc.date.available 2019-03-07T13:18:59Z
dc.date.issued 2019 es
dc.identifier.uri http://hdl.handle.net/10550/69464
dc.description.abstract The goal of this paper was to identify available biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw (BRONJ). Case-control studies comparing the different concentrations of a series of molecules detected in serum and urine as matrices of BRONJ affected patients vs. non-affected were included. PRISMA guidelines for systematic reviews were used for the present paper. Two reviewers independently screened electronic databases (Medline, Web of science, and The Cochrane Library) and performed hand searches. Risk of bias assessment of selected studies was performed by the Newcastle-Ottawa Scale. This study is registered as PROSPERO CRD42017078149. From a total of 601 identified studies, 7 (4 articles with high methodological quality and 3 with medium) articles were included. They investigate 2623 patients, of whom 91 (3.47%) developed BRONJ. A total of 7 biomarkers were identified and classified into 3 groups: bone turnover, angiogenesis and endocrine markers. Conflicting results were found in relation to most biomarkers. The present review suggests that no useful markers are currently available to evaluate BRONJ risk. Nevertheless, the present paper indicates that a paradigm shift from bone turnover biomarkers to angiogenesis and endocrine markers could shed light on this search. es
dc.source Lorenzo Pouso, A.I. ; Pérez-Sayáns, Mario ; González Palanca, Sergio ; Chamorro Petronacci, Cintia Micaela ; Bagán Sebastián, José Vicente ; García García, Abel. Biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw : a systematic review. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 24 1 2019: 5- es
dc.title Biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw : a systematic review es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.22763 es

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