Preemptive analgesia-related gene and protein expression in third molar surgeries under non steroidal anti-inflammatory drug protocols : A PROSPERO-registered systematic review of clinical studies
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Preemptive analgesia-related gene and protein expression in third molar surgeries under non steroidal anti-inflammatory drug protocols : A PROSPERO-registered systematic review of clinical studies

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Preemptive analgesia-related gene and protein expression in third molar surgeries under non steroidal anti-inflammatory drug protocols : A PROSPERO-registered systematic review of clinical studies

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dc.contributor.author Medeiros Albuquerque, Assis Filipe es
dc.contributor.author Sampaio-Melo, Carline-Maria es
dc.contributor.author Soares, Eduardo Costa Studart es
dc.contributor.author Rodrigues-Ribeiro, Thyciana es
dc.contributor.author Sá Roriz Fonteles, Cristiane es
dc.contributor.author Alves Pereira, Karuza Maria es
dc.contributor.author Ferreira-Barbosa, Daniel-Almeida es
dc.contributor.author Silva, Paulo-Goberlânio-de Barros es
dc.contributor.author Costa, Fabio Wildson Gurgel es
dc.date.accessioned 2019-02-14T08:20:57Z
dc.date.available 2019-02-14T08:20:57Z
dc.date.issued 2018 es
dc.identifier.uri http://hdl.handle.net/10550/68961
dc.description.abstract This study aimed to review translational studies focusing on third molar removal surgeries through a systematic analytical approach. A PROSPERO-registered systematic review (CRD42017060455) was conducted following the PRISMA statement to summarize current knowledge on gene expression in third molar surgeries. A search was performed in PubMed?s Medline and Scopus databases, without date or language restrictions, using the logical expression {[(Third molar) OR (preemptive) OR (cyclooxygenase inhibitors) OR (acute inflammation) AND (gene expression)]}. All studies included in the analysis evaluated gene expression in a third molar extraction model, using the preemptive analgesia methodology in seven investigations. The sample analyzed was obtained from gingival tissue biopsy (n=4), blood (n=1), transudate (n=1) and gingival tissue biopsy/transudate (n=1). There were differences with respect to evaluated genes, drug protocol, sample studied, and method for evaluating gene expression. Third molar surgeries were found to be associated with different COX-related gene expression patterns. Although inflammatory events following the surgical procedure are associated with COX isoforms, data from preemptive analgesia studies are scarce, especially from studies correlating gene expression and clinical parameters. In the future, from a clinical perspective, identifying the molecular targets of a drug based on individual gene expression may be helpful to delineate specific third molar, surgery-related, preemptive analgesia protocols. es
dc.source Medeiros Albuquerque, Assis Filipe ; Sampaio-Melo, Carline-Maria ; Soares, Eduardo Costa Studart ; Rodrigues-Ribeiro, Thyciana ; Sá Roriz Fonteles, Cristiane ; Alves Pereira, Karuza Maria ; Ferreira-Barbosa, Daniel-Almeida ; Silva, Paulo-Goberlânio-de Barros ; Costa, Fabio Wildson Gurgel. Preemptive analgesia-related gene and protein expression in third molar surgeries under non steroidal anti-inflammatory drug protocols : A PROSPERO-registered systematic review of clinical studies. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 23 6 2018: 12- es
dc.title Preemptive analgesia-related gene and protein expression in third molar surgeries under non steroidal anti-inflammatory drug protocols : A PROSPERO-registered systematic review of clinical studies es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.22576 es

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