Peptide Metal-Organic Frameworks for Enantioselective Separation of Chiral Drugs
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Peptide Metal-Organic Frameworks for Enantioselective Separation of Chiral Drugs

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Peptide Metal-Organic Frameworks for Enantioselective Separation of Chiral Drugs

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dc.contributor.author Navarro-Sánchez, José
dc.contributor.author Argente García, Ana Isabel
dc.contributor.author Moliner Martínez, Yolanda
dc.contributor.author Roca Sanjuán, Daniel
dc.contributor.author Antypov, Dmytro
dc.contributor.author Campíns Falcó, Pilar
dc.contributor.author Rosseinsky, Matthew J.
dc.contributor.author Martí Gastaldo, Carlos
dc.date.accessioned 2019-01-11T14:16:40Z
dc.date.available 2019-01-11T14:16:40Z
dc.date.issued 2017
dc.identifier.uri http://hdl.handle.net/10550/68465
dc.description.abstract We report the ability of a chiral Cu(II) 3D MOF based on the tripeptide Gly-L-His-Gly (GHG) for the enantioselective separation of metamphetamine and ephedrine. Monte Carlo simulations suggest that chiral recognition is linked to preferential binding of one of the enantiomers as result of either stronger or additional H-bonds with the framework that lead to energetically more stable diastereomeric adducts. Solid phase extraction (SPE) of a racemic mixture by using Cu(GHG) as extractive phase permits isolating more than 50% of the (+)-ephedrine enantiomer as target compound in only four minutes. To the best of our knowledge, this represents the first example of a MOF capable of separating chiral polar drugs.
dc.language.iso eng
dc.relation.ispartof Journal of the American Chemical Society, 2017, vol. 139, num. 12, p. 4294-4297
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Navarro-Sánchez, José Argente García, Ana Isabel Moliner Martínez, Yolanda Roca Sanjuán, Daniel Antypov, Dmytro Campíns Falcó, Pilar Rosseinsky, Matthew J. Martí Gastaldo, Carlos 2017 Peptide Metal-Organic Frameworks for Enantioselective Separation of Chiral Drugs Journal of the American Chemical Society 139 12 4294 4297
dc.subject Pèptids
dc.subject Química
dc.title Peptide Metal-Organic Frameworks for Enantioselective Separation of Chiral Drugs
dc.type info:eu-repo/semantics/article
dc.date.updated 2019-01-11T14:16:41Z
dc.identifier.doi https://doi.org/10.1021/jacs.7b00280
dc.identifier.idgrec 117899

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