The Interactions between host glycobiology, bacterial microbiota, and viruses in the gut
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The Interactions between host glycobiology, bacterial microbiota, and viruses in the gut

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The Interactions between host glycobiology, bacterial microbiota, and viruses in the gut

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dc.contributor.author Monedero García, Vicente
dc.contributor.author Buesa Gómez, Javier
dc.contributor.author Rodríguez Díaz, Jesús
dc.date.accessioned 2018-11-05T14:08:46Z
dc.date.available 2018-11-05T14:08:46Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10550/67852
dc.description.abstract Rotavirus (RV) and norovirus (NoV) are the major etiological agents of viral acute gastroenteritis worldwide. Host genetic factors, the histo-blood group antigens (HBGA), are associated with RV and NoV susceptibility and recent findings additionally point to HBGA as a factor modulating the intestinal microbial composition. In vitro and in vivo experiments in animal models established that the microbiota enhances RV and NoV infection, uncovering a triangular interplay between RV and NoV, host glycobiology, and the intestinal microbiota that ultimately influences viral infectivity. Studies on the microbiota composition in individuals displaying different RV and NoV susceptibilities allowed the identification of potential bacterial biomarkers, although mechanistic data on the virus-host-microbiota relation are still needed. The identification of the bacterial and HBGA interactions that are exploited by RV and NoV would place the intestinal microbiota as a new target for alternative therapies aimed at preventing and treating viral gastroenteritis.
dc.language.iso eng
dc.relation.ispartof Viruses, 2018, vol. 10, num. 2, p. e96
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Monedero García, Vicente Buesa Gómez, Javier Rodríguez Díaz, Jesús 2018 The Interactions between host glycobiology, bacterial microbiota, and viruses in the gut Viruses 10 2 e96
dc.subject Microbiologia
dc.subject Virus
dc.title The Interactions between host glycobiology, bacterial microbiota, and viruses in the gut
dc.type info:eu-repo/semantics/article
dc.date.updated 2018-11-05T14:08:47Z
dc.identifier.doi https://doi.org/10.3390/v10020096
dc.identifier.idgrec 128076

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