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Differential metallothionein expression in oral lichen planus and amalgam-associated oral lichenoid lesions

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Differential metallothionein expression in oral lichen planus and amalgam-associated oral lichenoid lesions

dc.contributor.author	Mendes, Gabriela-Geraldo	es
dc.contributor.author	Servato, João-Paulo-Silva	es
dc.contributor.author	Borges, Fabiana-Custódio	es
dc.contributor.author	Rosa, Roberta-Rezende	es
dc.contributor.author	Siqueira, Carla-Silva	es
dc.contributor.author	Faria, Paulo Rogério de	es
dc.contributor.author	Loyola, Adriano-Mota	es
dc.contributor.author	Vitorino Cardoso, Sérgio	es
dc.date.accessioned	2018-05-28T10:45:23Z
dc.date.available	2018-05-28T10:45:23Z
dc.date.issued	2018	es
dc.identifier.uri	http://hdl.handle.net/10550/66440
dc.description.abstract	Oral lichen planus (OLP) is a chronic inflammatory disease mediated by T cells, which manifests as reticular (white) or erosive (red) lesions, that are eventually painful. Oral lichenoid lesion (OLL) are distinguished from OLP by the presence of precipitating factors. The aim of this study was to evaluate whether the presence of metallothionein, which is involved in anti-apoptotic pathways and the anti-oxidative response, could serve as a differential diagnostic for OLP and OLL. We evaluated the expression of metallothionein in 40 cases of OLP and 20 cases of OLL using immunohistochemistry. White OLP has higher concentrations of metallothionein than red OLP in basal and parabasal layers. Moreover, metallothionein was more frequently observed in the cytoplasm and nuclei of basal cells in OLP patients compared to the same regions of OLL cases. Metallothionein levels are related to OLP severity and may contribute to a differential diagnosis between OLP and OLL.	es
dc.source	Mendes, Gabriela-Geraldo ; Servato, João-Paulo-Silva ; Borges, Fabiana-Custódio ; Rosa, Roberta-Rezende ; Siqueira, Carla-Silva ; Faria, Paulo Rogério de ; Loyola, Adriano-Mota ; Vitorino Cardoso, Sérgio. Differential metallothionein expression in oral lichen planus and amalgam-associated oral lichenoid lesions. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 23 3 2018: 3-	es
dc.title	Differential metallothionein expression in oral lichen planus and amalgam-associated oral lichenoid lesions	es
dc.type	info:eu-repo/semantics/article	en
dc.type	info:eu-repo/semantics/publishedVersion	en
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.22144	es