Exploring the Human-Nipah Virus Protein-Protein Interactome
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Exploring the Human-Nipah Virus Protein-Protein Interactome

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Exploring the Human-Nipah Virus Protein-Protein Interactome

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dc.contributor.author Martínez Gil, Luis
dc.contributor.author Vera Velasco, Natalia Mara
dc.contributor.author Mingarro Muñoz, Ismael
dc.date.accessioned 2018-05-14T16:45:46Z
dc.date.available 2018-05-14T16:45:46Z
dc.date.issued 2017
dc.identifier.uri http://hdl.handle.net/10550/66187
dc.description.abstract Nipah virus is an emerging, highly pathogenic, zoonotic virus of the Paramyxoviridae family. Human transmission occurs by close contact with infected animals, the consumption of contaminated food, or, occasionally, via other infected individuals. Currently, we lack therapeutic or prophylactic treatments for Nipah virus. To develop these agents we must now improve our understanding of the host-virus interactions that underpin a productive infection. This aim led us to perform the present work, in which we identified 101 human-Nipah virus protein-protein interactions (PPIs), most of which (88) are novel. This data set provides a comprehensive view of the host complexes that are manipulated by viral proteins. Host targets include the PRP19 complex and the microRNA (miRNA) processing machinery. Furthermore, we explored the biologic consequences of the interaction with the PRP19 complex and found that the Nipah virus W protein is capable of altering p53 control and gene expression. We anticipate that these data will help in guiding the development of novel interventional strategies to counter this emerging viral threat.
dc.language.iso eng
dc.relation.ispartof Journal of Virology, 2017, vol. 91, num. 23
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Martínez Gil, Luis Vera Velasco, Natalia M. Mingarro Muñoz, Ismael 2017 Exploring the Human-Nipah Virus Protein-Protein Interactome Journal of Virology 91 23
dc.subject Virologia
dc.subject Interaccions RNA-proteïna
dc.title Exploring the Human-Nipah Virus Protein-Protein Interactome
dc.type info:eu-repo/semantics/article
dc.date.updated 2018-05-14T16:45:47Z
dc.identifier.doi https://doi.org/10.1128/JVI.01461-17
dc.identifier.idgrec 121340

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