DNA multigene characterization of Fasciola hepatica and Lymnaea neotropica and its fascioliasis transmission capacity in Uruguay, with historical correlation, human report review and infection risk analysis
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DNA multigene characterization of Fasciola hepatica and Lymnaea neotropica and its fascioliasis transmission capacity in Uruguay, with historical correlation, human report review and infection risk analysis

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DNA multigene characterization of Fasciola hepatica and Lymnaea neotropica and its fascioliasis transmission capacity in Uruguay, with historical correlation, human report review and infection risk analysis

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dc.contributor.author Bargues Castelló, María Dolores
dc.contributor.author Gayo, Valeria
dc.contributor.author Sanchis, Jaime
dc.contributor.author Artigas Bascur, Patricio
dc.contributor.author Khoubbane, Messaoud
dc.contributor.author Birriel, Soledad
dc.contributor.author Mas-Coma, S.
dc.date.accessioned 2018-03-26T14:10:37Z
dc.date.available 2018-03-26T14:10:37Z
dc.date.issued 2017
dc.identifier.uri http://hdl.handle.net/10550/65519
dc.description.abstract Fascioliasis is a highly pathogenic zoonotic disease emerging in recent decades, in part due to the effects of climate and global changes. South America is the continent presenting more numerous human fascioliasis endemic areas and the highest Fasciola hepatica infection prevalences and intensities known in humans. These serious public health scenarios appear mainly linked to altitude areas in Andean countries, whereas lowland areas of non-Andean countries, such as Uruguay, only show sporadic human cases or outbreaks. To understand this difference, we characterized F. hepatica from cattle and horses and lymnaeids of Uruguay by sequencing of ribosomal DNA ITS-2 and ITS-1 spacers and mitochondrial DNA cox1, nad1 and 16S genes. Results indicate that vectors belong to Lymnaea neotropica instead of to Lymnaea viator, as always reported from Uruguay. Our correlation of fasciolid and lymnaeid haplotypes with historical data on the introduction and spread of livestock species into Uruguay allow to understand the molecular diversity detected. We study the life cycle and transmission features of F. hepatica by L. neotropica of Uruguay under standardized experimental conditions to enable a comparison with the transmission capacity of F. hepatica by Galba truncatula at very high altitude in Bolivia. Results demonstrate that although L. neotropica is a highly efficient vector in the lowlands, its transmission capacity is markedly lower than that of G. truncatula in the highlands. On this baseline, we review the human fascioliasis cases reported in Uruguay and analyze the present and future risk of human infection in front of future climate change estimations.
dc.language.iso eng
dc.relation.ispartof Plos Neglected Tropical Diseases, 2017, vol. 11, num. (2), p. e0005352
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Bargues Castelló, María Dolores Gayo, Valeria Sanchis, Jaime Artigas Bascur, Patricio Khoubbane, Messaoud Birriel, Soledad Mas-Coma, S. 2017 DNA multigene characterization of Fasciola hepatica and Lymnaea neotropica and its fascioliasis transmission capacity in Uruguay, with historical correlation, human report review and infection risk analysis Plos Neglected Tropical Diseases 11 (2) e0005352
dc.subject Parasitologia veterinària
dc.subject Bestiar
dc.title DNA multigene characterization of Fasciola hepatica and Lymnaea neotropica and its fascioliasis transmission capacity in Uruguay, with historical correlation, human report review and infection risk analysis
dc.type info:eu-repo/semantics/article
dc.date.updated 2018-03-26T14:10:37Z
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0005352
dc.identifier.idgrec 123946

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