Podoplanin expression in oral potentially malignant disorders and oral squamous cell carcinoma
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Podoplanin expression in oral potentially malignant disorders and oral squamous cell carcinoma

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Podoplanin expression in oral potentially malignant disorders and oral squamous cell carcinoma

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dc.contributor.author Deepa, A G es
dc.contributor.author Janardanan-Nair, Bindu es
dc.contributor.author Varun, B R es
dc.date.accessioned 2018-02-28T11:30:44Z
dc.date.available 2018-02-28T11:30:44Z
dc.date.issued 2017 es
dc.identifier.uri http://hdl.handle.net/10550/65087
dc.description.abstract Podoplanin is a type I transmembrane sialomucin-like glycoprotein that is specifically expressed in lymphatic endothelial cells. Studies have shown that assessment of podoplanin expression in the epithelial cells can be used to predict the malignant transformation of potentially malignant disorders and the metastatic tendency of primary head and neck squamous cell carcinoma. The aim of our study was to compare the expression of podoplanin in oral leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma with that in normal buccal mucosa by immunohistochemical methods. Immunohistochemical expression of podoplanin was analyzed in 20 cases each of oral leukoplakia, oral submucous fibrosis, oral squamous cell carcinoma and normal buccal mucosa, with monoclonal antibody D2-40. The expression of podoplanin was graded from grade 0-4. There was a statistically significant upregulation of the grades of podoplanin expression in oral squamous cell carcinoma(100%), oral submucous fibrosis (90%) and oral leukoplakia (65%) when compared to that in normal mucosa(35%). Podoplanin expression increased with decrease in grades of differentiation in oral squamous cell carcinoma . Podoplanin expression in the samples of oral submucous fibrosis was higher than that in oral leukoplakia. Evaluation of podoplanin expression in the epithelial cells of oral dysplastic lesions may provide valuable information to predict their risk of malignant transformation. es
dc.source Deepa, A G ; Janardanan-Nair, Bindu ; Varun, B R. Podoplanin expression in oral potentially malignant disorders and oral squamous cell carcinoma. En: Journal of Clinical and Experimental Dentistry, 9 12 2017: 1418-1424 es
dc.title Podoplanin expression in oral potentially malignant disorders and oral squamous cell carcinoma es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/jced.54213 es

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