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Oligonucleotide-Hybridization Fiber-Optic Biosensor using a Narrow Bandwidth Long Period Grating

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Oligonucleotide-Hybridization Fiber-Optic Biosensor using a Narrow Bandwidth Long Period Grating

dc.contributor.author	Delgado-Pinar, Martina
dc.contributor.author	Shi, Qing
dc.contributor.author	Poveda-Wong, Luis
dc.contributor.author	Delgado Pinar, Estefanía
dc.contributor.author	Xu, Baojian
dc.contributor.author	Zhao, Jianlog
dc.contributor.author	Cruz Muñoz, José Luis
dc.contributor.author	Andrés, Miguel V.
dc.date.accessioned	2018-02-23T08:01:18Z
dc.date.available	2018-02-23T08:01:18Z
dc.date.issued	2017	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/64886
dc.description.abstract	Nanometric narrowband Long Period Gratings (LPG) are investigated for the implementation of improved fiber optic biosensors. The reduction of more than one order of magnitude in the linewidth of the LPG with respect standard LPG at 1500 nm, leads to the improvement of the resolution of the sensor. By selecting the proper fabrication parameters (high numerical aperture, relatively high order mode and large length), LPGs with a 3-dB bandwidth of 1.5 nm were fabricated. The sensitivity of the LPG as a refractometer was calculated, and experimentally characterized in detail. In particular, the LP0,17 and LP0,18 resonances were investigated, in order to select the most suitable one for the bioexperiments. The surface of the LPG was functionalized and the detection of the hybridization of DNA is demonstrated. When the biosensor was immersed in a 2 μM solution of the complementary DNA strand, the resonances of the LPG shifted in wavelength. When measuring the response of the sensor in terms of variation of its transmittance as the resonance shifted in wavelength, the sensitivity was ~10%/μM for both resonances. The detection limit was estimated in 10 nM	es_ES
dc.language.iso	en	es_ES
dc.source	M. Delgado-Pinar, Q. Shi, L. Poveda-Wong, E. Delgado-Pinar, B. Xu, J. Zhao, J. L. Cruz and Miguel V. Andrés, "Oligonucleotide-hybridization fiber-optic biosensor using a narrow bandwidth long period grating", IEEE Sensors Journal,Vol. 17, pp. 5503-5509, 2017	es_ES
dc.subject	Fiber optics	es_ES
dc.subject	Fiber optics sensors	es_ES
dc.subject	Fiber gratings	es_ES
dc.subject	Biosensors	es_ES
dc.title	Oligonucleotide-Hybridization Fiber-Optic Biosensor using a Narrow Bandwidth Long Period Grating	es_ES
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::FÍSICA::Óptica ::Fibras ópticas	es_ES
dc.identifier.doi	10.1109/JSEN.2017.2723759	es_ES