Nutriosomes: prebiotic delivery systems combining phospholipid, soluble dextrin and curcumin to counteract intestinal oxidative stress and inflammation
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Nutriosomes: prebiotic delivery systems combining phospholipid, soluble dextrin and curcumin to counteract intestinal oxidative stress and inflammation

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Nutriosomes: prebiotic delivery systems combining phospholipid, soluble dextrin and curcumin to counteract intestinal oxidative stress and inflammation

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dc.contributor.author Catalán Latorre, Ana
dc.contributor.author Pleguezuelos-Villa, María
dc.contributor.author Castangia, Ines
dc.contributor.author Manca, Maria Letizia
dc.contributor.author Caddeo, Carla
dc.contributor.author Nácher Alonso, Amparo
dc.contributor.author Díez Sales, Octavio
dc.contributor.author Peris Ribera, José Esteban
dc.contributor.author Pons, Ramon
dc.contributor.author Escribano-Ferrer, Elvira
dc.contributor.author Fadda, Anna Maria
dc.contributor.author Manconi, Maria
dc.date.accessioned 2018-01-17T14:37:28Z
dc.date.available 2018-12-14T05:45:04Z
dc.date.issued 2017
dc.identifier.uri http://hdl.handle.net/10550/64016
dc.description.abstract Nutriosomes, new phospholipid nanovesicles specifically designed for intestinal protection were developed by simultaneously loading a water-soluble dextrine (Nutriose® FM06) and a natural antioxidant (curcumin). Nutriosomes were easily fabricated in a one-step, organic solvent-free procedure. The stability and the delivery performances of the vesicles were improved by adding hydroxypropylmetylcellulose. All the vesicles were small in size (mean diameter ~168 nm), negatively charged (zeta potential ~-38 mV, irrespective of their composition), self-assembled predominantly in unilamellar vesicles stabilized by the presence of Nutriose® , which was located in both the inter-lamellar and inter-vesicle medium, as confirmed by cryo-TEM and SAXS investigation. The dextrin acted also as a cryo-protector, avoiding vesicle collapse during the lyophilization process, and as a protector against high ionic strength and pH changes encountered in the gastrointestinal environment. Thanks to the antioxidant properties of curcumin, nutriosomes provided an optimal protective effect against hydrogen peroxide-induced oxidative stress in Caco-2 cells. Moreover, these innovative vesicles showed promising efficacy in vivo, as they improved the bioavailability and the biodistribution of both curcumin and dextrin upon oral administration, which acted synergically in reducing colonic damage chemically-induced in rats.
dc.language.iso eng
dc.relation.ispartof Nanoscale, 2017, p. 1-36
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Catalán Latorre, Ana Pleguezuelos-Villa, María Castangia, Ines Manca, Maria Letizia Caddeo, Carla Nácher Alonso, Amparo Díez Sales, Octavio Peris Ribera, José Esteban Pons, Ramon Escribano-Ferrer, Elvira Fadda, Anna Maria Manconi, Maria 2017 Nutriosomes: prebiotic delivery systems combining phospholipid, soluble dextrin and curcumin to counteract intestinal oxidative stress and inflammation Nanoscale 1 36
dc.subject Antioxidants
dc.subject Estrès oxidatiu
dc.title Nutriosomes: prebiotic delivery systems combining phospholipid, soluble dextrin and curcumin to counteract intestinal oxidative stress and inflammation
dc.type info:eu-repo/semantics/article
dc.date.updated 2018-01-17T14:37:28Z
dc.identifier.doi https://doi.org/10.1039/C7NR05929A
dc.identifier.idgrec 121774
dc.embargo.terms 1 year

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