Interactions between ibuprofen and antihypertensive drugs : Incidence and clinical relevance in dental practice
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Interactions between ibuprofen and antihypertensive drugs : Incidence and clinical relevance in dental practice

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Interactions between ibuprofen and antihypertensive drugs : Incidence and clinical relevance in dental practice

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dc.contributor.author Salort Llorca, Cesar es
dc.contributor.author Mínguez Serra, María Paz es
dc.contributor.author Silvestre Donat, Francisco Javier es
dc.date.accessioned 2017-12-16T08:26:04Z
dc.date.available 2017-12-16T08:26:04Z
dc.date.issued 2008 es
dc.identifier.uri http://hdl.handle.net/10550/63642
dc.description.abstract It has been well documented in the literature that ibuprofen interacts with different groups of antihypertensive drugs (beta-adrenergic blockers, alpha-adrenergic blockers, diuretics and angiotensin-converting enzyme inhibitors), reducing their antihypertensive activity. The mechanism of action of ibuprofen involves inhibition of the enzyme cyclooxygenase, thereby inhibiting the synthesis of inflammatory prostaglandins and vasodilatory prostaglandins that increase renal blood flow and thus favor the excretion of water and sodium. More than five days of treatment with both drugs are normally required for the interaction to manifest. Although the changes in blood pressure resulting from this interaction are typically small, some patients can experience substantial elevations in both systolic and diastolic blood pressure. It has been estimated that the avoidance of minor changes in systolic pressure in patients with osteoarthritis subjected to treatment with nonsteroidal antiinflammatory drugs would avoid over 30,000 deaths due to myocardial infarction, and over 2000 deaths due to coronary disease, in the United States alone. es
dc.source Salort Llorca, Cesar ; Mínguez Serra, María Paz ; Silvestre Donat, Francisco Javier. Interactions between ibuprofen and antihypertensive drugs : Incidence and clinical relevance in dental practice. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 13 11 2008: 9- es
dc.title Interactions between ibuprofen and antihypertensive drugs : Incidence and clinical relevance in dental practice es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi es

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